Klebsiella pneumoniae strain EuSCAPE_HR057

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR057 is a Gram-negative, rod-shaped bacterium characterized as a facultative anaerobe and a chemoheterotroph. It typically exists in various arrangements, including chains, pairs, and singles. This strain is motile due to the presence of flagella and thrives optimally at 37°C, classifying it as mesophilic. EuSCAPE_HR057 is predominantly host-associated, with a biotic relationship that allows it to exist freely in various environments. It has been identified in diverse hosts, including Homo sapiens, Gallus gallus, and several other metazoans and vertebrates. The strain is known for its significant pathogenicity in humans, causing a range of serious health effects such as bacteremia, pneumonia, urinary tract infections, and sepsis, among others. This strain has a simple genomic structure with one replicon and two membranes. Notably, it does not undergo sporulation. The wide range of infections it can cause, from urinary tract infections to liver abscesses and neonatal sepsis, highlights its adaptability and potential threat to human health. The ecological insight derived from the data indicates that Klebsiella pneumoniae strain EuSCAPE_HR057 has a versatile lifestyle, capable of thriving in both human hosts and environmental reservoirs. Its pathogenic potential, combined with its ability to inhabit various organisms, underscores the importance of monitoring this strain in clinical settings to mitigate its impact on public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR057

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR057
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR057 genome assembly,

Gene Summary

Adenine Count

1194236 bp

Thymine Count

1193891 bp

Guanine Count

1588626 bp

Cytosine Count

1577130 bp

Genome Length

5553883 bp

Protein-coding Genes

4952 genes

Non-Coding Genes

331 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
multidrug transporter mdtbSAMEA3721089_00984Not AvailableNegative1025534 - 1028656112278.0
rnd efflux membrane fusion proteinSAMEA3721089_00985Not AvailableNegative1028656 - 102989443395.3
c4-dicarboxylate transport proteinSAMEA3721089_00986Not AvailablePositive1030195 - 103146945002.4
positive transcription regulatorSAMEA3721089_00987Not AvailableNegative1031743 - 103235423124.2
uncharacterised proteinSAMEA3721089_00988Not AvailableNegative1032470 - 10326105773.26
putative response regulator receiverSAMEA3721089_00989Not AvailableNegative1032848 - 103354925986.3
histidine kinaseSAMEA3721089_00990Not AvailableNegative1033564 - 103542068978.8
heat shock protein yegdSAMEA3721089_00991Not AvailableNegative1035710 - 103706248925.6
dna-3-methyladenine glycosylase iiSAMEA3721089_00992Not AvailablePositive1037200 - 103804830922.4
uridine kinaseSAMEA3721089_00993Not AvailablePositive1038163 - 103880424421.6

Displaying genes 1231 – 1240 of 5283 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total