Klebsiella pneumoniae strain EuSCAPE_HR059

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR059 is a Gram-negative, rod-shaped bacterium that exhibits facultative anaerobic metabolism, utilizing a chemoheterotrophic energy source. It is capable of forming chains, pairs, and singles, and possesses flagella, allowing for mobility. This strain thrives optimally at 37°C and falls within the mesophilic temperature range. EuSCAPE_HR059 is primarily host-associated, displaying a free-living biotic relationship. It has a diverse host range, including Homo sapiens, Gallus gallus, and various other vertebrates such as Canis lupus familiaris and Sus scrofa, as well as members of the plant kingdom like Viridiplantae. The strain is notable for its pathogenicity in humans, being implicated in a variety of serious health issues, including bacteremia, urinary tract infections, pneumonia, and sepsis, among others. With a single replicon and a double membrane structure, Klebsiella pneumoniae strain EuSCAPE_HR059 is nonsporulating. The strain's ability to cause a wide spectrum of infections highlights its potential impact on both human health and veterinary medicine. The presence of this bacterium in multiple hosts suggests an ecological versatility and adaptability, contributing to its role as a significant opportunistic pathogen. Its ability to thrive in diverse environments underscores the importance of monitoring and managing Klebsiella pneumoniae in clinical and ecological contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR059

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR059
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR059 genome assembly,

Gene Summary

Adenine Count

1157376 bp

Thymine Count

1154152 bp

Guanine Count

1558639 bp

Cytosine Count

1551778 bp

Genome Length

5421945 bp

Protein-coding Genes

4938 genes

Non-Coding Genes

245 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
gnat family acetyltransferaseSAMEA3721091_01132Not AvailablePositive1134926 - 113548921221.1
uncharacterised proteinSAMEA3721091_01133Not AvailablePositive1135711 - 113625920982.5
uncharacterised proteinSAMEA3721091_01134Not AvailableNegative1136273 - 113696224725.1
cytochrome c heme lyase subunit ccmhSAMEA3721091_01135Not AvailableNegative1137497 - 113833930475.0
cytochrome c heme lyase subunit ccmlSAMEA3721091_01136Not AvailableNegative1138336 - 113879417051.9
cytochrome c-type biogenesis protein ccmg/dsbe, thiol:disulfide oxidoreductaseSAMEA3721091_01137Not AvailableNegative1138794 - 113934821035.5
cytochrome c heme lyase subunit ccmfSAMEA3721091_01138Not AvailableNegative1139345 - 114129772322.0
cytochrome c-type biogenesis protein ccme, heme chaperoneSAMEA3721091_01139Not AvailableNegative1141294 - 114175216754.2
cytochrome c-type biogenesis protein ccmd, interacts with ccmceSAMEA3721091_01140Not AvailableNegative1141736 - 11419668424.06
cytochrome c-type biogenesis protein ccmc, putative heme lyase for ccmeSAMEA3721091_01141Not AvailableNegative1141963 - 114270027458.4

Displaying genes 1301 – 1310 of 5183 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total