Klebsiella pneumoniae strain EuSCAPE_HR046

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR046 is a Gram-negative, rod-shaped bacterium classified as a facultative anaerobe. This strain is a chemoheterotroph, meaning it derives its energy from organic compounds. It typically exists in various arrangements, including chains, pairs, and singles. EuSCAPE_HR046 possesses flagella, granting it motility, and has a mesophilic temperature range, with an optimal growth temperature of 37°C. This strain is notably pathogenic to humans, associated with a wide array of serious health effects. These include bacteremia, urinary tract infections, pneumonia, and more severe conditions such as meningitis and sepsis. Its ability to infect multiple hosts, including Homo sapiens, Gallus gallus, and various other metazoan and plant species, indicates a broad ecological niche. Klebsiella pneumoniae EuSCAPE_HR046 is nonsporulating and has a single replicon and double membrane structure. The presence of diverse pathogenic effects underscores its significance in clinical microbiology and public health, particularly in hospital settings where it may lead to nosocomial infections. Given its pathogenic potential and wide host range, EuSCAPE_HR046 exemplifies the adaptability and resilience of Klebsiella pneumoniae in various environments. Its free-living biotic relationship suggests that it can thrive in diverse biological contexts, contributing to its role as a human pathogen. Understanding the traits of this strain is crucial for developing strategies to mitigate its impact on health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR046

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR046
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR046 genome assembly,

Gene Summary

Adenine Count

1162814 bp

Thymine Count

1160928 bp

Guanine Count

1569124 bp

Cytosine Count

1558027 bp

Genome Length

5450893 bp

Protein-coding Genes

4964 genes

Non-Coding Genes

245 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
lipoprotein releasing system atp-binding protein loldSAMEA3721072_03279Not AvailableNegative3437186 - 343788725577.0
lipoprotein releasing system transmembrane protein lolcSAMEA3721072_03280Not AvailableNegative3437880 - 343907943174.4
transcription-repair coupling factorSAMEA3721072_03281Not AvailablePositive3439384 - 3442830130020.0
lysm domain/erfk/ybis/ycfs/ynhg family proteinSAMEA3721072_03282Not AvailablePositive3442994 - 344395334427.7
outer membrane proteinSAMEA3721072_03283Not AvailableNegative3444082 - 34443398655.25
transcriptional regulator tetr familySAMEA3721072_03284Not AvailablePositive3444589 - 344522423250.7
putative tonb-dependent receptorSAMEA3721072_03285Not AvailablePositive3445468 - 344765780478.3
17 kda surface antigenSAMEA3721072_03286Not AvailableNegative3447715 - 344825418805.4
fad-dependent pyridine nucleotide-disulfide oxidoreductaseSAMEA3721072_03287Not AvailableNegative3448449 - 344975347260.7
ycfp proteinSAMEA3721072_03288Not AvailableNegative3449999 - 345054121077.2

Displaying genes 3431 – 3440 of 5209 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total