Klebsiella pneumoniae strain EuSCAPE_HR046

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR046 is a Gram-negative, rod-shaped bacterium classified as a facultative anaerobe. This strain is a chemoheterotroph, meaning it derives its energy from organic compounds. It typically exists in various arrangements, including chains, pairs, and singles. EuSCAPE_HR046 possesses flagella, granting it motility, and has a mesophilic temperature range, with an optimal growth temperature of 37°C. This strain is notably pathogenic to humans, associated with a wide array of serious health effects. These include bacteremia, urinary tract infections, pneumonia, and more severe conditions such as meningitis and sepsis. Its ability to infect multiple hosts, including Homo sapiens, Gallus gallus, and various other metazoan and plant species, indicates a broad ecological niche. Klebsiella pneumoniae EuSCAPE_HR046 is nonsporulating and has a single replicon and double membrane structure. The presence of diverse pathogenic effects underscores its significance in clinical microbiology and public health, particularly in hospital settings where it may lead to nosocomial infections. Given its pathogenic potential and wide host range, EuSCAPE_HR046 exemplifies the adaptability and resilience of Klebsiella pneumoniae in various environments. Its free-living biotic relationship suggests that it can thrive in diverse biological contexts, contributing to its role as a human pathogen. Understanding the traits of this strain is crucial for developing strategies to mitigate its impact on health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR046

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR046
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR046 genome assembly,

Gene Summary

Adenine Count

1162814 bp

Thymine Count

1160928 bp

Guanine Count

1569124 bp

Cytosine Count

1558027 bp

Genome Length

5450893 bp

Protein-coding Genes

4964 genes

Non-Coding Genes

245 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
slt family transglycosylaseSAMEA3721072_02123Not AvailablePositive2216907 - 221852361119.3
pp_02089SAMEA3721072_02124Not AvailableNegative2218520 - 2219029Not Available
had superfamily (subfamily if) hydrolase, yfhbSAMEA3721072_02125Not AvailableNegative2219092 - 221972724268.6
sialic acid utilization regulatorSAMEA3721072_02126Not AvailablePositive2219941 - 222078930713.2
4fe-4s ferredoxinSAMEA3721072_02127Not AvailablePositive2220846 - 22211069769.74
holo-[acyl-carrier protein] synthaseSAMEA3721072_02128Not AvailableNegative2221119 - 222149914038.0
pyridoxine 5'-phosphate synthaseSAMEA3721072_02129Not AvailableNegative2221499 - 222223026474.0
dna recombination and repair protein recoSAMEA3721072_02130Not AvailableNegative2222242 - 222297927435.0
gtp-binding protein eraSAMEA3721072_02131Not AvailableNegative2222991 - 222389633885.1
ribonuclease iiiSAMEA3721072_02132Not AvailableNegative2223893 - 222457325558.6

Displaying genes 2291 – 2300 of 5209 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total