Klebsiella pneumoniae strain EuSCAPE_HR038

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR038 is a Gram-negative, rod-shaped bacterium that exhibits mobility due to the presence of flagella. It is classified as a facultative anaerobe and is a chemoheterotroph, relying on organic compounds for energy. This strain typically exists in various arrangements, including chains, pairs, and singles, and is adapted to a mesophilic temperature range with an optimal growth temperature of 37°C. K. pneumoniae strain EuSCAPE_HR038 is associated with multiple hosts, including Homo sapiens, various birds, mammals, and plants, indicating its versatility in colonization and pathogenicity across different biological kingdoms. The strain is notably pathogenic to humans, being implicated in a wide array of health issues such as bacteremia, urinary tract infections, pneumonia, and various abdominal infections. Its ability to cause serious conditions like sepsis and neonatal sepsis highlights its significance in clinical microbiology. This bacterium is nonsporulating and possesses a single replicon and double membranes, which are characteristic features of its cell structure. The free-living biotic relationship of K. pneumoniae suggests that it can thrive independently in various environments, including those associated with human activities. The ecological insights from K. pneumoniae strain EuSCAPE_HR038 underscore the importance of monitoring this pathogen, particularly in healthcare settings, due to its potential to cause severe infections in humans and its adaptability to different hosts. Understanding its traits and pathogenic potential can aid in developing strategies to mitigate its impact on public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR038

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR038
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR038 genome assembly,

Gene Summary

Adenine Count

1186321 bp

Thymine Count

1198464 bp

Guanine Count

1609581 bp

Cytosine Count

1573891 bp

Genome Length

5568257 bp

Protein-coding Genes

5015 genes

Non-Coding Genes

236 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
phosphocarrier proteinSAMEA3721057_03046Not AvailableNegative3289185 - 32894579807.75
p-loop-containing kinaseSAMEA3721057_03047Not AvailableNegative3289454 - 329030832543.2
pts system transporter subunit iia-like nitrogen-regulatory protein ptsnSAMEA3721057_03048Not AvailableNegative3290354 - 329084217705.3
ribosome hibernation protein yhbhSAMEA3721057_03049Not AvailableNegative3290913 - 329120010760.0
rna polymerase sigma-54 factor rponSAMEA3721057_03050Not AvailableNegative3291223 - 329265653927.9
lipopolysaccharide abc transporterSAMEA3721057_03051Not AvailableNegative3292704 - 329342926844.4
lpta, protein essential for lps transport across the periplasmSAMEA3721057_03052Not AvailableNegative3293436 - 329398119863.8
lipopolysaccharide exporter periplasmic proteinSAMEA3721057_03053Not AvailableNegative3293950 - 329452521662.7
3-deoxy-d-manno-octulosonate 8-phosphate phosphataseSAMEA3721057_03054Not AvailableNegative3294522 - 329508820402.7
d-arabinose 5-phosphate isomeraseSAMEA3721057_03055Not AvailableNegative3295103 - 329608935115.8

Displaying genes 3071 – 3080 of 5251 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total