Klebsiella pneumoniae strain EuSCAPE_HR038

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR038 is a Gram-negative, rod-shaped bacterium that exhibits mobility due to the presence of flagella. It is classified as a facultative anaerobe and is a chemoheterotroph, relying on organic compounds for energy. This strain typically exists in various arrangements, including chains, pairs, and singles, and is adapted to a mesophilic temperature range with an optimal growth temperature of 37°C. K. pneumoniae strain EuSCAPE_HR038 is associated with multiple hosts, including Homo sapiens, various birds, mammals, and plants, indicating its versatility in colonization and pathogenicity across different biological kingdoms. The strain is notably pathogenic to humans, being implicated in a wide array of health issues such as bacteremia, urinary tract infections, pneumonia, and various abdominal infections. Its ability to cause serious conditions like sepsis and neonatal sepsis highlights its significance in clinical microbiology. This bacterium is nonsporulating and possesses a single replicon and double membranes, which are characteristic features of its cell structure. The free-living biotic relationship of K. pneumoniae suggests that it can thrive independently in various environments, including those associated with human activities. The ecological insights from K. pneumoniae strain EuSCAPE_HR038 underscore the importance of monitoring this pathogen, particularly in healthcare settings, due to its potential to cause severe infections in humans and its adaptability to different hosts. Understanding its traits and pathogenic potential can aid in developing strategies to mitigate its impact on public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR038

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR038
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR038 genome assembly,

Gene Summary

Adenine Count

1186321 bp

Thymine Count

1198464 bp

Guanine Count

1609581 bp

Cytosine Count

1573891 bp

Genome Length

5568257 bp

Protein-coding Genes

5015 genes

Non-Coding Genes

236 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
phosphoribosylaminoimidazole-succinocarboxamide synthaseSAMEA3721057_01611Not AvailablePositive1767801 - 176851426879.4
ypfj protein, zinc metalloprotease superfamilySAMEA3721057_01612Not AvailablePositive1768634 - 176950931877.4
methionine trna cytidine acetyltransferaseSAMEA3721057_01613Not AvailablePositive1769519 - 177152272937.1
esterase ypfhSAMEA3721057_01614Not AvailablePositive1771599 - 177229425137.9
inner membrane proteinSAMEA3721057_01615Not AvailableNegative1772343 - 17725498327.94
n-succinyl-l,l-diaminopimelate desuccinylaseSAMEA3721057_01616Not AvailableNegative1772576 - 177370341372.6
a glutathione-dependent thiol reductaseSAMEA3721057_01617Not AvailableNegative1773707 - 177406013477.3
aminoglycoside efflux pumpSAMEA3721057_01618Not AvailableNegative1774613 - 1777726112839.0
pyridine nucleotide-disulfide oxidoreductase family proteinSAMEA3721057_01619Not AvailablePositive1778099 - 178008171401.0
nudix hydrolase family protein yffhSAMEA3721057_01620Not AvailablePositive1780140 - 178073622158.3

Displaying genes 1731 – 1740 of 5251 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total