Klebsiella pneumoniae strain EuSCAPE_HR022

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_HR022 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, utilizing chemoheterotrophic energy sources. It is characterized by its ability to arrange in chains, pairs, or as single cells, and it possesses flagella, indicating mobility. This strain thrives optimally at 37°C, within a mesophilic temperature range, and has a single replicon with a double membrane structure. This bacterium is associated with a wide range of hosts, including Homo sapiens, various birds (Gallus gallus, Phasianidae), mammals (Canis lupus familiaris, Sus scrofa, Equidae), amphibians, and fish (Danio rerio). Its free-living nature allows it to adapt and persist in diverse environments, including those associated with human activity. Klebsiella pneumoniae has significant health implications, being associated with various infections such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The strain's pathogenicity is primarily directed toward humans, contributing to a spectrum of diseases that can range from mild to severe, including neonatal sepsis and intra-abdominal infections. The ecological insight into Klebsiella pneumoniae strain EuSCAPE_HR022 highlights its role as both a commensal and a pathogen within different biological systems. Understanding its interactions within various hosts and environments can provide valuable information for managing infections and reducing the impact of this opportunistic pathogen in clinical settings.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_HR022

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_HR022
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_HR022 genome assembly,

Gene Summary

Adenine Count

1148410 bp

Thymine Count

1144353 bp

Guanine Count

1550360 bp

Cytosine Count

1535487 bp

Genome Length

5378610 bp

Protein-coding Genes

4870 genes

Non-Coding Genes

256 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
ribosomal large subunit pseudouridine synthase bSAMEA3721026_03407Not AvailablePositive3566414 - 356731633849.6
cob(i)alamin adenosyltransferaseSAMEA3721026_03408Not AvailableNegative3567376 - 356796621889.1
short chain dehydrogenaseSAMEA3721026_03409Not AvailableNegative3567963 - 356876329551.8
peptidase s49 domain-containing proteinSAMEA3721026_03410Not AvailablePositive3568943 - 357002540284.0
protein ycinSAMEA3721026_03411Not AvailableNegative3570073 - 35703249481.22
dna topoisomerase iSAMEA3721026_03412Not AvailablePositive3570731 - 357332897301.9
cys regulon transcriptional activator cysbSAMEA3721026_03413Not AvailablePositive3573674 - 357464835965.2
uncharacterised proteinSAMEA3721026_03414Not AvailablePositive3574894 - 35750616320.91
aconitate hydrataseSAMEA3721026_03415Not AvailablePositive3575450 - 357812297556.5
gtp cyclohydrolase iiSAMEA3721026_03416Not AvailableNegative3578169 - 357877122183.7

Displaying genes 3521 – 3530 of 5126 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total