Klebsiella pneumoniae strain EuSCAPE_UK032

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_UK032 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, sourcing its energy as a chemoheterotroph. This strain is characterized by its ability to exist in various arrangements, including chains, pairs, and singles. It is motile due to the presence of flagella and thrives optimally at 37°C, making it mesophilic in nature. This bacterium is associated with a wide range of hosts, including humans (Homo sapiens), various mammals, birds, and plants, indicating its versatility in adapting to different ecological niches. The strain is noted for its pathogenicity in humans, being implicated in numerous health conditions such as bacteremia, urinary tract infections, pneumonia, and meningitis, among others. These infections can lead to severe complications, including sepsis and endophthalmitis, emphasizing the strain's role as a significant human pathogen. Klebsiella pneumoniae EuSCAPE_UK032 is nonsporulating and possesses a single replicon and two membranes. It typically engages in free-living biotic relationships, which may contribute to its environmental resilience and ability to infect various hosts. The ecological insight gleaned from its broad host range and pathogenic potential highlights the importance of understanding Klebsiella pneumoniae in both clinical and environmental contexts. Its adaptability and virulence underscore the need for ongoing research into its behavior and the mechanisms underlying its infections, particularly given the challenges posed by antibiotic resistance in this species.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_UK032

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_UK032
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_UK032 genome assembly,

Gene Summary

Adenine Count

1198485 bp

Thymine Count

1200043 bp

Guanine Count

1594271 bp

Cytosine Count

1606101 bp

Genome Length

5598900 bp

Protein-coding Genes

5072 genes

Non-Coding Genes

281 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
16s ribosomal rnaNot AvailableNot AvailablePositive215369 - 216896Not Available
membrane-bound lytic murein transglycosylase eSAMEA3720920_00193Not AvailableNegative215554 - 21616522359.1
muramoyltetrapeptide carboxypeptidaseSAMEA3720920_00194Not AvailablePositive216341 - 21725533423.1
cell volume regulation protein aSAMEA3720920_00195Not AvailablePositive217348 - 21908162178.2
alanine racemaseSAMEA3720920_00196Not AvailableNegative219098 - 22016838734.0
d-amino acid dehydrogenase small subunitSAMEA3720920_00197Not AvailableNegative220178 - 22147647203.8
spovr family proteinSAMEA3720920_00198Not AvailablePositive221798 - 22333060578.7
fatty acid metabolism regulatorSAMEA3720920_00199Not AvailableNegative223405 - 22412427090.4
sodium/proton antiporterSAMEA3720920_00200Not AvailablePositive224373 - 22592356786.1
disulfide bond formation protein bSAMEA3720920_00201Not AvailablePositive226052 - 22658220066.3

Displaying genes 431 – 440 of 5353 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total