Klebsiella pneumoniae strain EuSCAPE_LU018

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_LU018 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, categorizing it as a chemoheterotroph. It is capable of existing in various arrangements, including chains, pairs, and singles, and possesses flagella, which contributes to its mobility. This strain thrives optimally at a temperature of 37°C, indicating its mesophilic nature. K. pneumoniae EuSCAPE_LU018 is primarily host-associated, with a broad range of hosts, such as Homo sapiens, Gallus gallus, and various other Metazoa and Aves. It is known to cause numerous health issues in humans, including bacteremia, urinary tract infections, pneumonia, and meningitis, among others. The pathogen's significant role in severe infections, such as neonatal sepsis and septicemia, underscores its clinical importance. The bacterium has a unique ecological niche as a free-living organism, yet it is also a significant opportunistic pathogen in human health. With its ability to thrive in diverse environments and its pathogenic potential, K. pneumoniae EuSCAPE_LU018 exemplifies the complex interplay between environmental adaptability and host-associated pathogenicity. Its presence in various hosts may facilitate interspecies transmission and the evolution of antibiotic resistance, further complicating treatment options for infections it may cause.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_LU018

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_LU018
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_LU018 genome assembly,

Gene Summary

Adenine Count

1266789 bp

Thymine Count

1262520 bp

Guanine Count

1644662 bp

Cytosine Count

1672243 bp

Genome Length

5846214 bp

Protein-coding Genes

5302 genes

Non-Coding Genes

304 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
conjugal transfer protein trbfSAMEA3672970_05285Not AvailablePositive5529048 - 552949116848.0
conjugal transfer pilus assembly protein trahSAMEA3672970_05286Not AvailablePositive5529457 - 553084851000.2
conjugal transfer mating pair stabilization protein tragSAMEA3672970_05287Not AvailablePositive5530848 - 5533697103191.0
conjugal transfer entry exclusion protein trasSAMEA3672970_05288Not AvailablePositive5533700 - 553423019897.0
conjugal transfer surface exclusion protein tratSAMEA3672970_05289Not AvailablePositive5534420 - 553515125796.9
conjugal transfer protein tradSAMEA3672970_05290Not AvailablePositive5535509 - 553781885948.6
conjugal transfer nickase/helicase traiSAMEA3672970_05291Not AvailablePositive5537818 - 5543076190364.0
type-f conjugative transfer system pilin acetylase traxSAMEA3672970_05292Not AvailablePositive5543166 - 554389126798.4
conjugal transfer fertility inhibition protein finoSAMEA3672970_05293Not AvailablePositive5543963 - 554455921958.0
uncharacterised proteinSAMEA3672970_05294Not AvailablePositive5544579 - 554492613435.1

Displaying genes 5301 – 5310 of 5606 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total