Klebsiella pneumoniae strain EuSCAPE_LU018

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_LU018 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, categorizing it as a chemoheterotroph. It is capable of existing in various arrangements, including chains, pairs, and singles, and possesses flagella, which contributes to its mobility. This strain thrives optimally at a temperature of 37°C, indicating its mesophilic nature. K. pneumoniae EuSCAPE_LU018 is primarily host-associated, with a broad range of hosts, such as Homo sapiens, Gallus gallus, and various other Metazoa and Aves. It is known to cause numerous health issues in humans, including bacteremia, urinary tract infections, pneumonia, and meningitis, among others. The pathogen's significant role in severe infections, such as neonatal sepsis and septicemia, underscores its clinical importance. The bacterium has a unique ecological niche as a free-living organism, yet it is also a significant opportunistic pathogen in human health. With its ability to thrive in diverse environments and its pathogenic potential, K. pneumoniae EuSCAPE_LU018 exemplifies the complex interplay between environmental adaptability and host-associated pathogenicity. Its presence in various hosts may facilitate interspecies transmission and the evolution of antibiotic resistance, further complicating treatment options for infections it may cause.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_LU018

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_LU018
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_LU018 genome assembly,

Gene Summary

Adenine Count

1266789 bp

Thymine Count

1262520 bp

Guanine Count

1644662 bp

Cytosine Count

1672243 bp

Genome Length

5846214 bp

Protein-coding Genes

5302 genes

Non-Coding Genes

304 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
xylose isomeraseSAMEA3672970_02723Not AvailableNegative2887246 - 288856849883.7
xylose abc transporter, periplasmic xylose-binding protein xylfSAMEA3672970_02724Not AvailablePositive2889063 - 289005835886.3
d-xylose transport atp-binding protein xylgSAMEA3672970_02725Not AvailablePositive2890123 - 289166456349.6
d-xylose transport system permease componentSAMEA3672970_02726Not AvailablePositive2891642 - 289282340980.5
xylose activator xylr (arac family)SAMEA3672970_02727Not AvailablePositive2893056 - 289423444950.8
mannosyl-glycoprotein endo-beta-n-acetylglucosamidaseSAMEA3672970_02728Not AvailableNegative2894273 - 289483621295.3
periplasmic alpha-amylaseSAMEA3672970_02729Not AvailablePositive2895406 - 289743975944.3
valine-pyruvate aminotransferaseSAMEA3672970_02730Not AvailablePositive2897610 - 289886647013.1
electron transport protein hydnSAMEA3672970_02731Not AvailableNegative2898909 - 289939417408.2
selenocysteine-specific translation elongation factorSAMEA3672970_02732Not AvailableNegative2899639 - 290148068531.5

Displaying genes 2881 – 2890 of 5606 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total