Klebsiella pneumoniae strain EuSCAPE_RS033

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_RS033 is a Gram-negative, facultative anaerobic bacterium that exhibits a rod shape and can be found in various arrangements, including chains, pairs, and singles. This strain is classified as a chemoheterotroph, deriving its energy from organic compounds. It possesses flagella, indicating mobility, and thrives optimally at a temperature of 37°C, categorizing it as mesophilic. This bacterium is free-living yet is also associated with a range of hosts, which include Homo sapiens, Gallus gallus, and various other Metazoa and plants. Its pathogenic potential is significant, as it is known to cause numerous health effects in humans, such as bacteremia, urinary tract infections, pneumonia, and sepsis. The strain is involved in severe clinical conditions like neonatal sepsis and pyogenic liver abscesses, highlighting its role as a serious opportunistic pathogen, particularly in immunocompromised individuals. The presence of a single replicon and two membranes is characteristic of this organism, contributing to its complex interactions within host environments. The ecological and biological insights derived from the host associations suggest that Klebsiella pneumoniae strain EuSCAPE_RS033 has adapted well to diverse ecological niches, which may facilitate its transmission and survival in both human and animal populations. Understanding these traits is crucial for developing targeted interventions to mitigate the health risks associated with this versatile pathogen.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_RS033

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_RS033
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_RS033 genome assembly,

Gene Summary

Adenine Count

1191643 bp

Thymine Count

1195714 bp

Guanine Count

1595146 bp

Cytosine Count

1561548 bp

Genome Length

5544051 bp

Protein-coding Genes

4952 genes

Non-Coding Genes

345 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
respiratory nitrate reductase subunit alphaSAMEA3721154_01859Not AvailableNegative1897518 - 1901258139859.0
nitrate/nitrite transport protein naruSAMEA3721154_01860Not AvailableNegative1901356 - 190273849510.5
transcriptional regulator tetr familySAMEA3721154_01861Not AvailableNegative1902913 - 190344919945.2
methyl viologen resistance protein smvaSAMEA3721154_01862Not AvailablePositive1903612 - 190511151651.3
pca regulon regulatory protein pcarSAMEA3721154_01863Not AvailableNegative1905106 - 190590328325.7
l-ala-d/l-glu epimeraseSAMEA3721154_01864Not AvailablePositive1906157 - 190727538961.9
muconolactone isomeraseSAMEA3721154_01865Not AvailablePositive1907295 - 190758511284.6
catechol 1,2-dioxygenaseSAMEA3721154_01866Not AvailablePositive1907652 - 190857834276.3
2-chlorobenzoate 1,2-dioxygenase, alpha subunitSAMEA3721154_01867Not AvailablePositive1908688 - 191007052476.7
benzoate 1,2-dioxygenase subunit betaSAMEA3721154_01868Not AvailablePositive1910070 - 191055519332.6

Displaying genes 2061 – 2070 of 5297 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total