Klebsiella pneumoniae strain EuSCAPE_UK127

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_UK127 is a Gram-negative, rod-shaped bacterium exhibiting a facultative anaerobic metabolism and belonging to the chemoheterotroph category. This strain is characterized by its mobility, facilitated by the presence of flagella, and typically forms chains, pairs, or singles in its cell arrangement. It thrives optimally at 37°C, indicating a mesophilic nature. This strain is notably associated with various hosts, including Homo sapiens and other species such as Gallus gallus, Danio rerio, and Canis lupus familiaris. It is recognized for its pathogenic potential in humans, being implicated in multiple health issues, such as bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Other significant health effects include sepsis and neonatal sepsis, underscoring the strain's relevance in clinical settings. Klebsiella pneumoniae EuSCAPE_UK127 is nonsporulating and possesses a single replicon contained within two membranes, typical of Gram-negative bacteria. Its biotic relationships suggest it can exist freely in the environment while also adapting to exploit various host organisms. The ecological insight drawn from the data indicates that Klebsiella pneumoniae strain EuSCAPE_UK127 plays a dual role, acting both as a free-living organism in diverse environments and as a significant pathogen in multiple hosts, particularly humans. This versatility underscores the importance of monitoring such strains in both clinical and environmental microbiology contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_UK127

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_UK127
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_UK127 genome assembly,

Gene Summary

Adenine Count

1193257 bp

Thymine Count

1192600 bp

Guanine Count

1597303 bp

Cytosine Count

1589430 bp

Genome Length

5572590 bp

Protein-coding Genes

5006 genes

Non-Coding Genes

230 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
iron binding protein isca for iron-sulfur cluster assemblySAMEA3673091_01210Not AvailableNegative1295402 - 129572511449.5
iron-sulfur cluster assembly scaffold protein iscuSAMEA3673091_01211Not AvailableNegative1295743 - 129612913807.3
cysteine desulfuraseSAMEA3673091_01212Not AvailableNegative1296156 - 129737045059.1
iron-sulfur cluster regulator iscrSAMEA3673091_01213Not AvailableNegative1297549 - 129804017551.9
trna:cm32/um32 methyltransferaseSAMEA3673091_01214Not AvailableNegative1298275 - 129900926799.4
inositol-1-monophosphataseSAMEA3673091_01215Not AvailablePositive1299130 - 129993329322.0
uncharacterised proteinSAMEA3673091_01216Not AvailableNegative1299980 - 130081630794.7
transporter ni2+-co2+ transporter (nicot) familySAMEA3673091_01217Not AvailableNegative1300916 - 130189635013.0
membrane proteinSAMEA3673091_01218Not AvailableNegative1301887 - 130252523534.9
stationary phase inducible protein csieSAMEA3673091_01219Not AvailablePositive1302650 - 130392749096.0

Displaying genes 1331 – 1340 of 5236 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total