Klebsiella pneumoniae strain EuSCAPE_UK070

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_UK070 is a Gram-negative, rod-shaped, and facultative anaerobic bacterium that primarily resides in host-associated environments. As a chemoheterotroph, it derives energy from organic compounds and exhibits mobility due to the presence of flagella. This strain typically forms chains, pairs, or exists as single cells, adapting its arrangement based on environmental conditions. The optimal growth temperature for EuSCAPE_UK070 is 37°C, classifying it as mesophilic, which aligns with its association with warm-blooded hosts. The bacterium has a single replicon and is characterized by a double membrane structure. It can be free-living but is commonly found in diverse hosts, including Homo sapiens, various birds, mammals, and even some aquatic species. Klebsiella pneumoniae strain EuSCAPE_UK070 is notably pathogenic to humans, causing a wide range of serious health issues such as bacteremia, urinary tract infections, pneumonia, and sepsis. Its capacity to cause infections extends to neonatal sepsis and pulmonary infections, highlighting its clinical significance. The strain is also associated with infections in other species, indicating its ecological versatility and potential impact on both human health and veterinary medicine. The diverse array of hosts and the range of infections associated with EuSCAPE_UK070 underscore its adaptive nature and the importance of monitoring this strain in clinical settings. Understanding its pathogenic mechanisms can inform treatment strategies and public health measures to mitigate the risks posed by this bacterium in both human and animal populations.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_UK070

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_UK070
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_UK070 genome assembly,

Gene Summary

Adenine Count

1185519 bp

Thymine Count

1174759 bp

Guanine Count

1554974 bp

Cytosine Count

1594869 bp

Genome Length

5510121 bp

Protein-coding Genes

5067 genes

Non-Coding Genes

87 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
amino acid abc transporterSAMEA3720943_00076Not AvailableNegative82253 - 8301728326.1
amino acid abc transporter periplasmic amino acid-binding proteinSAMEA3720943_00077Not AvailableNegative83081 - 8384827701.2
putative transcriptional regulatorSAMEA3720943_00078Not AvailableNegative83941 - 8484332681.8
putative iron compound abc transport system periplasmic binding componentSAMEA3720943_00079Not AvailableNegative84840 - 8579335002.0
permease of ferrichrome abc transporterSAMEA3720943_00080Not AvailableNegative85807 - 8685936748.8
iron compound permease protein of abc transporter familySAMEA3720943_00081Not AvailableNegative86856 - 8788134816.3
transportSAMEA3720943_00082Not AvailableNegative87878 - 8869930006.4
tonb-dependent siderophore receptorSAMEA3720943_00083Not AvailablePositive89205 - 9127775514.5
alkanesulfonates abc transporter atp-binding protein / sulfonate abc transporterSAMEA3720943_00084Not AvailableNegative91741 - 9251428146.5
alkanesulfonates transport system permease proteinSAMEA3720943_00085Not AvailableNegative92508 - 9350336099.9

Displaying genes 81 – 90 of 5154 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total