Klebsiella pneumoniae strain EuSCAPE_PT074

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_PT074 is a Gram-negative, rod-shaped bacterium exhibiting a range of pathogenic effects primarily in humans. This strain is categorized as a facultative anaerobe, capable of thriving in both aerobic and anaerobic conditions, with an optimal growth temperature of 37°C, making it mesophilic. It is noteworthy for its mobility, facilitated by the presence of flagella, and its ability to form chains, pairs, or exist as singles. In terms of habitat, EuSCAPE_PT074 is host-associated and demonstrates a free-living biotic relationship. The strain is a chemoheterotroph, deriving energy from organic compounds. It is known to infect various hosts, including Homo sapiens, Gallus gallus, and several other metazoans, indicating its broad host range. Clinically, Klebsiella pneumoniae strain EuSCAPE_PT074 is associated with numerous serious health conditions. These include bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections, among others. Its pathogenicity is particularly concerning in human health, as it can lead to severe complications such as sepsis and neonatal sepsis. The presence of this strain in diverse animal hosts suggests an ecological adaptability, allowing it to thrive in various environments. This adaptability, combined with its pathogenic potential, raises important considerations for public health and infection control, particularly in settings where human and animal interactions are prevalent.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_PT074

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_PT074
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_PT074 genome assembly,

Gene Summary

Adenine Count

1155870 bp

Thymine Count

1150245 bp

Guanine Count

1544527 bp

Cytosine Count

1550008 bp

Genome Length

5400650 bp

Protein-coding Genes

4897 genes

Non-Coding Genes

251 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Terminase/oxidoreductaseSAMEA3649888_02887Not AvailableNegative3079257 - 308101166705.2
Capsid scaffolding proteinSAMEA3649888_02888Not AvailablePositive3081161 - 308199430765.8
P2 family major capsid proteinSAMEA3649888_02889Not AvailablePositive3082011 - 308307539623.9
Small terminase subunitSAMEA3649888_02890Not AvailablePositive3083079 - 308372923932.8
Head completion-stabilization proteinSAMEA3649888_02891Not AvailablePositive3083826 - 308429017528.5
Tail proteinSAMEA3649888_02892Not AvailablePositive3084290 - 30844937431.76
HolinSAMEA3649888_02893Not AvailablePositive3084497 - 30847128062.0
LysozymeSAMEA3649888_02894Not AvailablePositive3084693 - 308520218409.3
Hypothetical proteinSAMEA3649888_02895Not AvailablePositive3085207 - 308559013947.7
Lysb family lysis regulatory proteinSAMEA3649888_02896Not AvailablePositive3085587 - 308601515906.2

Displaying genes 21 – 30 of 5148 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total