Klebsiella pneumoniae strain EuSCAPE_PT045

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_PT045 is a Gram-negative, rod-shaped bacterium that thrives in host-associated environments. It is classified as a facultative anaerobe, utilizing a chemoheterotrophic energy source, allowing it to grow in both aerobic and anaerobic conditions. This strain is capable of mobility, possessing flagella, and typically forms chains, pairs, and singles. Optimal growth occurs at 37°C, placing it within the mesophilic temperature range. The bacterium has a single chromosomal replicon and is characterized by two membranes, which is a common feature of Gram-negative bacteria. It exhibits a free-living lifestyle, with a diverse array of potential hosts, including Homo sapiens, various avian species, and several mammals such as Gallus gallus, Sus scrofa, and Canis lupus familiaris. K. pneumoniae strain EuSCAPE_PT045 is associated with a wide range of health complications in humans, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Its pathogenicity is significant, as it can lead to severe conditions such as sepsis, neonatal sepsis, and emphysematous pyelonephritis. The ecological role of this strain, particularly within human and animal hosts, underscores its adaptability and potential impact on health. Its ability to thrive in various biological environments highlights the importance of monitoring and understanding its pathogenic capabilities, especially in the context of increasing antibiotic resistance in Klebsiella species.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_PT045

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_PT045
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_PT045 genome assembly,

Gene Summary

Adenine Count

1207910 bp

Thymine Count

1200108 bp

Guanine Count

1593320 bp

Cytosine Count

1605869 bp

Genome Length

5607207 bp

Protein-coding Genes

5136 genes

Non-Coding Genes

186 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
oligopeptide abc transporterSAMEA3649859_00253Not AvailableNegative266482 - 26818562286.0
chloramphenicol acetyltransferaseSAMEA3649859_00254Not AvailableNegative268530 - 26921325426.4
lactoylglutathione lyaseSAMEA3649859_00255Not AvailableNegative269245 - 26962813711.1
transcriptional regulators of sugar metabolismSAMEA3649859_00256Not AvailablePositive269720 - 27049027683.6
amino acid exporterSAMEA3649859_00257Not AvailableNegative270495 - 27112422508.4
carbonic anhydraseSAMEA3649859_00258Not AvailablePositive271374 - 27200923245.8
protein of uncharacterised function (duf1471)SAMEA3649859_00259Not AvailableNegative272321 - 2725307256.63
response regulator receiver proteinSAMEA3649859_00260Not AvailableNegative272638 - 27333026448.4
cadc family transcriptional regulatorSAMEA3649859_00261Not AvailableNegative273376 - 27381016724.6
uncharacterised proteinSAMEA3649859_00262Not AvailablePositive274212 - 2743615537.78

Displaying genes 371 – 380 of 5322 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total