Klebsiella pneumoniae strain EuSCAPE_GR153

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain EuSCAPE_GR153 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism as a chemoheterotroph. It can thrive in various environments, being host-associated and capable of existing in chains, pairs, or as single cells. This strain is notable for its mobility, facilitated by the presence of flagella, and has an optimal growth temperature of 37°C, categorizing it as mesophilic. EuSCAPE_GR153 is significant in clinical microbiology due to its association with a range of serious health effects in humans, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. Its pathogenicity extends to other hosts, such as Gallus gallus (chickens), Sus scrofa (pigs), and Canis lupus familiaris (dogs), among others. This broad host range indicates a versatile ecological adaptability, allowing it to colonize various environments and organisms. The strain is nonsporulating and possesses a single replicon and two membranes, which are characteristic features of Gram-negative bacteria. Given its ability to cause severe infections, including septicemia and neonatal sepsis, Klebsiella pneumoniae strain EuSCAPE_GR153 underscores the importance of monitoring and understanding the dynamics of pathogenic bacteria in clinical settings. Its role in human health and disease highlights the interconnectedness of microbial life and the necessity for vigilance in public health efforts, particularly concerning antibiotic resistance and infection control measures.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain EuSCAPE_GR153

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain EuSCAPE_GR153
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain EuSCAPE_GR153 genome assembly,

Gene Summary

Adenine Count

1199042 bp

Thymine Count

1211404 bp

Guanine Count

1618099 bp

Cytosine Count

1593356 bp

Genome Length

5621901 bp

Protein-coding Genes

5091 genes

Non-Coding Genes

190 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
gcn5-like n-acetyltransferaseSAMEA3649772_00491Not AvailablePositive491179 - 49169719788.6
cytochrome c heme lyase subunit ccmhSAMEA3649772_00492Not AvailableNegative491962 - 49280430549.1
cytochrome c heme lyase subunit ccmlSAMEA3649772_00493Not AvailableNegative492801 - 49325916952.7
cytochrome c-type biogenesis protein ccmg/dsbe, thiol:disulfide oxidoreductaseSAMEA3649772_00494Not AvailableNegative493259 - 49381321035.5
cytochrome c heme lyase subunit ccmfSAMEA3649772_00495Not AvailableNegative493810 - 49576272374.1
cytochrome c-type biogenesis protein ccme, heme chaperoneSAMEA3649772_00496Not AvailableNegative495759 - 49621716767.2
cytochrome c-type biogenesis protein ccmd, interacts with ccmceSAMEA3649772_00497Not AvailableNegative496201 - 4964318394.03
cytochrome c-type biogenesis protein ccmc, putative heme lyase for ccmeSAMEA3649772_00498Not AvailableNegative496428 - 49716527428.4
heme exporter permease componentSAMEA3649772_00499Not AvailableNegative497215 - 49787422936.4
abc transporter atpase ccmaSAMEA3649772_00500Not AvailableNegative497871 - 49849422358.1

Displaying genes 621 – 630 of 5281 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total