Escherichia coli strain NCTC10429

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain NCTC10429 is a Gram-negative, rod-shaped bacterium characterized as a facultative anaerobe, allowing it to thrive in varying oxygen conditions. This strain exhibits mobility through the presence of flagella and typically arranges itself in singles and pairs. It is mesophilic, with an optimal growth temperature of 37°C. NCTC10429 is associated with a variety of hosts, including Homo sapiens, Gallus gallus, Bos taurus, and several other animals and plants, indicating a broad ecological niche. The strain possesses a single replicon and is structurally composed of two membranes. It is recognized for its free-living biotic relationships, which further facilitates its interaction with multiple hosts. Clinically, E. coli NCTC10429 is linked to numerous health issues in humans, such as urinary tract infections (UTIs), gastrointestinal infections, and neonatal meningitis, among others. It is notorious for causing severe conditions like hemolytic uremic syndrome (HUS) and septicemia, highlighting its pathogenic potential. The strain's ability to infect a wide range of hosts, coupled with its diverse pathogenic effects, underscores its ecological adaptability and significance in both environmental and clinical microbiology. Understanding the traits of E. coli NCTC10429 can aid in developing effective prevention and treatment strategies for the various diseases it causes, emphasizing the need for ongoing research in microbial pathogenesis.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain NCTC10429

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain NCTC10429
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain NCTC10429 genome assembly, contig:

Gene Summary

Adenine Count

1221920 bp

Thymine Count

1221170 bp

Guanine Count

1261024 bp

Cytosine Count

1255603 bp

Genome Length

4959717 bp

Protein-coding Genes

5928 genes

Non-Coding Genes

508 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
altronate hydrolaseNCTC10429_01378Not AvailablePositive1037519 - 103900654180.3
inner membrane proteinNCTC10429_01379Not AvailablePositive1039089 - 103964020576.8
putative transport proteinNCTC10429_01380Not AvailableNegative1039645 - 104088943480.4
putative ph-induced membrane-bound redox modulatorNCTC10429_01381Not AvailableNegative1041505 - 104247035983.1
putative oxidoreductaseNCTC10429_01383Not AvailableNegative1042766 - 10429817895.52
putative oxidoreductaseNCTC10429_01384Not AvailableNegative1042998 - 104374427303.4
thioredoxin-like proteinNCTC10429_01385Not AvailableNegative1043823 - 104450625236.0
metal dependent hydrolaseNCTC10429_01386Not AvailableNegative1044583 - 104508619456.6
putative enzymeNCTC10429_01387Not AvailablePositive1045172 - 104630842378.8
translation-dependent mrna interferase, toxin of the higb-higa toxin-antitoxin systemNCTC10429_01388Not AvailablePositive1046593 - 104690712103.7

Displaying genes 1881 – 1890 of 6436 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total