Escherichia coli strain NCTC9050

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain NCTC9050 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism. This strain is characterized by its mobility, facilitated by the presence of flagella, and typically thrives at an optimal temperature of 37°C, falling within the mesophilic temperature range. NCTC9050 is notable for its ability to exist in pairs or singles and possesses a double membrane structure. This strain is primarily host-associated, with a wide range of potential hosts, including various mammals (e.g., Homo sapiens, Bos taurus, and Canis lupus familiaris), birds (e.g., Gallus gallus and Meleagris gallopavo), and even plants (e.g., Solanum lycopersicum). This diverse range of hosts indicates a significant ecological adaptability and potential for interaction across different biological kingdoms. NCTC9050 is associated with numerous health effects, particularly in humans, where it is implicated in urinary tract infections (UTIs), gastrointestinal infections, and severe conditions such as neonatal meningitis and hemolytic uremic syndrome (HUS). Its pathogenicity highlights its role as a significant opportunistic pathogen in clinical settings, capable of causing a variety of diseases from mild diarrhea to severe systemic infections. The ecological insight derived from the diversity of hosts and the range of diseases linked to E. coli NCTC9050 underscores the importance of this strain in both environmental and clinical contexts. Its ability to thrive in multiple habitats and cause various health issues illustrates the complex interplay between microbial species and their hosts, emphasizing the need for ongoing research into its pathogenic mechanisms and ecological roles.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain NCTC9050

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain NCTC9050
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain NCTC9050 genome assembly, contig:

Gene Summary

Adenine Count

1442772 bp

Thymine Count

1443291 bp

Guanine Count

1475436 bp

Cytosine Count

1482786 bp

Genome Length

5844285 bp

Protein-coding Genes

4997 genes

Non-Coding Genes

658 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
uncharacterised proteinNCTC9050_02282Not AvailablePositive2313239 - 231355612212.2
n-acetylneuraminic acid outer membrane porinNCTC9050_02283Not AvailablePositive2314434 - 231515027889.4
n-acetylneuraminic acid mutarotaseNCTC9050_02284Not AvailablePositive2315170 - 231627639494.1
yjhs proteinNCTC9050_02285Not AvailablePositive2316340 - 231732036898.1
putative restriction endonucleaseNCTC9050_02286Not AvailablePositive2317532 - 231840433275.6
mcrc family protein, mcrbc 5-methylcytosine restriction system componentNCTC9050_02287Not AvailableNegative2318467 - 231977750909.2
mcrb family protein, gtpase subunit of restriction endonucleaseNCTC9050_02288Not AvailableNegative2319774 - 232182878721.2
restriction methylaseNCTC9050_02289Not AvailableNegative2322186 - 232301932101.3
type i restriction-modification system, m subunitNCTC9050_02290Not AvailablePositive2323325 - 232488157727.0
type i restriction-modification enzyme s subunitNCTC9050_02291Not AvailablePositive2324878 - 232613147879.6

Displaying genes 2481 – 2490 of 5655 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total