Klebsiella pneumoniae strain 1812040001 lung abscess API 5205773

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain 1812040001 is a Gram-negative, rod-shaped bacterium notable for its pathogenicity in humans. This strain is a facultative anaerobe and exhibits mobility due to the presence of flagella. It typically forms chains, pairs, and singles, adapting to various habitats, primarily host-associated environments. As a chemoheterotroph, it derives energy from organic compounds, thriving optimally at 37°C within a mesophilic temperature range. Strain 1812040001 has a complex biotic relationship, being free-living but significantly impacting multiple hosts, including Homo sapiens, Gallus gallus, and various other vertebrates and invertebrates. Its pathogenic profile is extensive, linked to numerous serious health effects such as bacteremia, pneumonia, urinary tract infections, and liver abscesses. Infections can manifest in various forms, including neonatal sepsis and septicemia, indicating the strain's potential to cause severe systemic illnesses. With a single replicon and a double membrane structure, Klebsiella pneumoniae strain 1812040001 exemplifies the adaptability and resilience of this bacterium in diverse ecological niches. Its ability to infect a wide range of hosts illustrates its evolutionary success and highlights the importance of monitoring such pathogens in clinical and environmental settings to mitigate health risks associated with their spread. Understanding the specific characteristics and behaviors of this strain can inform prevention and treatment strategies in human and veterinary medicine.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain 1812040001 lung abscess API 5205773

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain 1812040001 lung abscess API 5205773
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain 1812040001 lung abscess API 5205773

Gene Summary

Adenine Count

1151066 bp

Thymine Count

1152852 bp

Guanine Count

1559754 bp

Cytosine Count

1546442 bp

Genome Length

5410114 bp

Protein-coding Genes

5074 genes

Non-Coding Genes

241 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Regulatory cii family proteinFCG31_10220Not AvailableNegative2088855 - 208936418144.0
RegulatorFCG31_10225Not AvailableNegative2089397 - 20896188265.09
Repressor protein ciFCG31_10230Not AvailablePositive2089707 - 209064835807.7
Hypothetical proteinFCG31_10235Not AvailablePositive2090651 - 209170040272.1
AttrNot AvailableNot AvailablePositive2092042 - 2092054Not Available
Tyrosine-type recombinase/integraseFCG31_10240Not AvailablePositive2092397 - 209342839332.9
AttlNot AvailableNot AvailablePositive3649728 - 3649742Not Available
Hypothetical proteinFCG31_18090Not AvailablePositive3650491 - 365078711306.8
Putative anti-repressor proteinFCG31_18095Not AvailablePositive3651102 - 365179125570.7
hypothetical proteinFCG31_18100Not AvailablePositive3651986 - 365261824864.4

Displaying genes 41 – 50 of 5315 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total