Klebsiella pneumoniae strain SIKP052 57_NODE_86

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain SIKP052 (57_NODE_86) is a Gram-negative, rod-shaped bacterium known for its facultative anaerobic metabolism and chemoheterotrophic energy source. This strain typically resides in host-associated habitats and exhibits mobility, facilitated by the presence of flagella. It can be found in various arrangements, including singles, pairs, and chains. With an optimal growth temperature of 37°C, SIKP052 falls under mesophilic organisms, capable of thriving in moderate temperature ranges. It possesses a single replicon and is characterized by a double membrane structure, common among Gram-negative bacteria. This strain is notably pathogenic to humans and has been associated with a wide array of health complications, including bacteremia, urinary tract infections, pneumonia, and various intra-abdominal infections. It has also been implicated in severe conditions such as sepsis, neonatal sepsis, and liver abscesses. Beyond humans, SIKP052 has potential interactions with a diverse range of hosts, including various mammals (e.g., Canis lupus familiaris, Ovis aries), birds (e.g., Gallus gallus, Phasianidae), and aquatic species like Danio rerio. The ecological and biological implications of Klebsiella pneumoniae strain SIKP052 highlight the bacterium's adaptability and potential for pathogenicity across multiple hosts, suggesting its role in environmental reservoirs and the importance of monitoring its presence in clinical and non-clinical settings.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain SIKP052 57_NODE_86

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain SIKP052 57_NODE_86
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain SIKP052 57_NODE_86, whole genome

Gene Summary

Adenine Count

1177018 bp

Thymine Count

1178680 bp

Guanine Count

1575889 bp

Cytosine Count

1578010 bp

Genome Length

5509597 bp

Protein-coding Genes

5130 genes

Non-Coding Genes

303 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
iclr family transcriptional regulatorFAQ86_00140Not AvailableNegative29521 - 3031828222.5
muconate cycloisomeraseFAQ86_00145Not AvailablePositive30572 - 3169038956.9
muconolactone delta-isomeraseFAQ86_00150Not AvailablePositive31710 - 3200011212.5
catechol 1,2-dioxygenaseFAQ86_00155Not AvailablePositive32067 - 3299334290.3
benzoate 1,2-dioxygenase large subunitFAQ86_00160Not AvailablePositive33103 - 3448552476.7
benzoate 1,2-dioxygenase small subunitFAQ86_00165Not AvailablePositive34485 - 3497019314.6
2fe-2s iron-sulfur cluster binding domain-containing proteinFAQ86_00170Not AvailablePositive34980 - 3599636649.9
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenaseFAQ86_00175Not AvailablePositive36006 - 3677927284.4
drug/metabolite dmt transporter permeaseFAQ86_00180Not AvailableNegative36776 - 3765431378.2
formate dehydrogenase-n subunit alphaFAQ86_00185Not AvailablePositive37880 - 40927112939.0

Displaying genes 281 – 290 of 5433 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total