Klebsiella pneumoniae strain KP4CR KP4CR_83

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain KP4CR (accession SETX00000000.1) is a Gram-negative, rod-shaped bacterium characterized by its facultative anaerobic metabolism and chemoheterotrophic energy source. This strain exhibits a diverse cell arrangement, forming chains, pairs, and singles, and possesses flagella, indicating mobility. KP4CR thrives optimally at 37°C within a mesophilic temperature range and has a biotic relationship classified as free-living. This strain is notable for its significant pathogenicity in humans, being associated with a wide range of infections, including bacteremia, urinary tract infections (UTIs), pneumonia, and various intra-abdominal infections such as liver abscesses and sepsis. Its pathogenic profile also includes severe conditions like neonatal sepsis and endophthalmitis, reflecting its capacity to affect multiple systems and populations. The host range for KP4CR is broad, encompassing not only humans (Homo sapiens) but also various animals including Gallus gallus, Danio rerio, and Sus scrofa. This versatility in hosts suggests that KP4CR may play a role in both environmental and clinical contexts, highlighting its ecological significance in diverse habitats. Overall, the ability of Klebsiella pneumoniae strain KP4CR to thrive in various hosts and its association with serious health effects underscore its importance as a pathogen in both human and veterinary medicine. Understanding its ecological interactions may aid in developing strategies to mitigate its impact on health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain KP4CR KP4CR_83

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain KP4CR KP4CR_83
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain KP4CR KP4CR_83, whole genome shotgun

Gene Summary

Adenine Count

1187509 bp

Thymine Count

1190198 bp

Guanine Count

1594827 bp

Cytosine Count

1582998 bp

Genome Length

5561952 bp

Protein-coding Genes

5236 genes

Non-Coding Genes

236 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
purine ribonucleoside efflux pump nepiEWP76_26940Not AvailablePositive5371821 - 537301441647.4
phosphonoacetaldehyde hydrolaseEWP76_26945Not AvailableNegative5373011 - 537382028805.4
2-aminoethylphosphonate--pyruvate transaminaseEWP76_26950Not AvailableNegative5373830 - 537493340550.6
hypothetical proteinEWP76_26955Not AvailablePositive5374924 - 53751187441.07
phosphonate utilization transcriptional regulator phnrEWP76_26960Not AvailablePositive5375075 - 537579427525.2
2-aminoethylphosphonate abc transporter substrate-binding proteinEWP76_26965Not AvailablePositive5375973 - 537698636281.8
2-aminoethylphosphonate abc transport system atp-binding subunit phntEWP76_26970Not AvailablePositive5376992 - 537810439950.7
2-aminoethylphosphonate abc transporter permease subunitEWP76_26975Not AvailablePositive5378104 - 537896430955.2
2-aminoethylphosphonate abc transport system, membrane component phnvEWP76_26980Not AvailablePositive5378967 - 537976428363.5
hypothetical proteinEWP76_26985Not AvailableNegative5379963 - 53801506840.1

Displaying genes 5281 – 5290 of 5475 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total