Klebsiella pneumoniae strain KP8CR

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain KP8CR is a Gram-negative, rod-shaped bacterium that thrives in host-associated environments, demonstrating facultative anaerobic metabolism as a chemoheterotroph. This strain is characterized by its mobility, facilitated by the presence of flagella, and typically forms chains, pairs, or exists as singles. It has an optimal growth temperature of 37°C and falls within the mesophilic temperature range. K. pneumoniae KP8CR is known to have significant pathogenicity in humans, causing a variety of serious health issues, including bacteremia, pneumonia, urinary tract infections, and sepsis. The strain is also implicated in various infections affecting different animal hosts, including mammals, birds, and amphibians, revealing its potential as a zoonotic pathogen. This extensive host range indicates its adaptability and ecological versatility. In terms of genetic structure, KP8CR possesses a single replicon and features two membranes, consistent with the typical architecture of Gram-negative bacteria. The bacterium does not undergo sporulation, which is a trait shared by many pathogenic bacteria that rely on other survival strategies. The widespread health effects associated with K. pneumoniae KP8CR underline its importance in both clinical and ecological contexts. The strain's ability to infect multiple hosts suggests that it plays a significant role in the microbial ecology of various environments and can contribute to the transmission of antimicrobial resistance among different species. Understanding its biology and pathogenicity is crucial for managing infections and developing effective treatment strategies.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain KP8CR

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain KP8CR
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain KP8CR scaffold_195, whole genome

Gene Summary

Adenine Count

1189458 bp

Thymine Count

1188451 bp

Guanine Count

1601058 bp

Cytosine Count

1597990 bp

Genome Length

5591512 bp

Protein-coding Genes

5316 genes

Non-Coding Genes

212 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
carbamoyl-phosphate synthase small subunitEWP71_22600Not AvailableNegative4514223 - 451537141204.9
4-hydroxy-tetrahydrodipicolinate reductaseEWP71_22605Not AvailableNegative4515829 - 451665028707.4
triphosphoribosyl-dephospho-coa synthase citgEWP71_22610Not AvailableNegative4516879 - 451778732548.4
citrate lyase subunit alphaEWP71_22615Not AvailableNegative4517806 - 451933254661.5
citrate (pro-3s)-lyase subunit betaEWP71_22620Not AvailableNegative4519343 - 452021231353.7
citrate lyase acyl carrier proteinEWP71_22625Not AvailableNegative4520209 - 452050210427.7
[citrate (pro-3s)-lyase] ligaseEWP71_22630Not AvailableNegative4520533 - 452156138504.9
citrate/sodium symporter citnEWP71_22635Not AvailablePositive4521818 - 452315847504.7
oxaloacetate decarboxylase subunit gammaEWP71_22640Not AvailablePositive4523314 - 45235658856.16
oxaloacetate decarboxylase subunit alphaEWP71_22645Not AvailablePositive4523581 - 452534762027.7

Displaying genes 4421 – 4430 of 5529 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total