Helicobacter pylori strain ZH127 42

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain ZH127 42 is a microaerophilic, gram-negative bacterium characterized by its spirilla shape and single-cell arrangement. This strain possesses a flagella, which aids in its mobility, although mobility is noted as 'no' in this context. Its optimal growth temperature is 37°C, indicating a mesophilic nature, and it has a single replicon and two membranes. ZH127 42 is primarily associated with a variety of hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, Cricetinae, and Thais. The organism is known to have multiple health effects in humans, including chronic gastric inflammation, gastric ulcers, and various forms of cancer such as gastric adenocarcinoma and MALT lymphoma. It is implicated in several gastrointestinal diseases, including GERD and functional dyspepsia. The biotic relationship of ZH127 42 is classified as free-living, suggesting it can survive outside of specific host environments, although it is predominantly found in association with its hosts. The bacterium's pathogenicity is confirmed in humans, linking it to serious health conditions. The ecological insight from ZH127 42's traits highlights its significant role in human health, particularly in relation to gastrointestinal diseases. Its presence in diverse hosts underscores its adaptability and potential for cross-species transmission, which may contribute to the prevalence of gastric diseases across different populations.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain ZH127 42

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain ZH127 42
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH127 42, whole genome shotgun

Gene Summary

Adenine Count

504915 bp

Thymine Count

511106 bp

Guanine Count

326364 bp

Cytosine Count

325253 bp

Genome Length

1670564 bp

Protein-coding Genes

1473 genes

Non-Coding Genes

64 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
khg/kdpg aldolaseEC593_06900Not AvailablePositive1406522 - 140714822572.0
sel1-like repeat protein hcpcEC593_06905Not AvailablePositive1407218 - 140809031496.6
sdr family oxidoreductaseEC593_06910Not AvailableNegative1408288 - 140904027934.9
hypothetical proteinEC593_06915Not AvailableNegative1409058 - 141059357811.5
Trna-alaNot AvailableNot AvailablePositive1411223 - 1411298Not Available
Trna-ileNot AvailableNot AvailablePositive1411316 - 1411392Not Available
udp-glucose 4-epimerase galeEC593_06935Not AvailablePositive1411507 - 141254138739.6
trna pseudouridine(38-40) synthase truaEC593_06940Not AvailableNegative1412535 - 141326327213.3
lptf/lptg family permeaseEC593_06945Not AvailableNegative1413265 - 141430239691.0
protein-l-isoaspartate o-methyltransferaseEC593_06950Not AvailableNegative1414324 - 141495323905.1

Displaying genes 1331 – 1340 of 1541 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total