Helicobacter pylori strain ZH127 42

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain ZH127 42 is a microaerophilic, gram-negative bacterium characterized by its spirilla shape and single-cell arrangement. This strain possesses a flagella, which aids in its mobility, although mobility is noted as 'no' in this context. Its optimal growth temperature is 37°C, indicating a mesophilic nature, and it has a single replicon and two membranes. ZH127 42 is primarily associated with a variety of hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, Cricetinae, and Thais. The organism is known to have multiple health effects in humans, including chronic gastric inflammation, gastric ulcers, and various forms of cancer such as gastric adenocarcinoma and MALT lymphoma. It is implicated in several gastrointestinal diseases, including GERD and functional dyspepsia. The biotic relationship of ZH127 42 is classified as free-living, suggesting it can survive outside of specific host environments, although it is predominantly found in association with its hosts. The bacterium's pathogenicity is confirmed in humans, linking it to serious health conditions. The ecological insight from ZH127 42's traits highlights its significant role in human health, particularly in relation to gastrointestinal diseases. Its presence in diverse hosts underscores its adaptability and potential for cross-species transmission, which may contribute to the prevalence of gastric diseases across different populations.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain ZH127 42

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain ZH127 42
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH127 42, whole genome shotgun

Gene Summary

Adenine Count

504915 bp

Thymine Count

511106 bp

Guanine Count

326364 bp

Cytosine Count

325253 bp

Genome Length

1670564 bp

Protein-coding Genes

1473 genes

Non-Coding Genes

64 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
methyltransferase domain-containing proteinEC593_05440Not AvailableNegative1126166 - 112690328311.2
preprotein translocase subunit secgEC593_05445Not AvailablePositive1127020 - 112761021228.6
ribosome recycling factorEC593_05450Not AvailablePositive1127610 - 112816720928.1
orotate phosphoribosyltransferaseEC593_05455Not AvailablePositive1128171 - 112877621932.8
rdd family proteinEC593_05460Not AvailablePositive1128766 - 112923017977.6
nad-dependent deacylaseEC593_05465Not AvailablePositive1129227 - 112991625964.3
nad(p)h-quinone oxidoreductase subunit 3EC593_05470Not AvailablePositive1130024 - 113042515647.8
nadh-quinone oxidoreductase subunit bEC593_05475Not AvailablePositive1130425 - 113090417837.9
nadh-quinone oxidoreductase subunit cEC593_05480Not AvailablePositive1130901 - 113170131486.8
nadh dehydrogenase (quinone) subunit dEC593_05485Not AvailablePositive1131703 - 113293246689.4

Displaying genes 1051 – 1060 of 1541 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total