Helicobacter pylori strain ZH68 56

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain ZH68 56 is a microaerophilic, gram-negative bacterium characterized by its spirilla shape and presence of flagella, allowing for motility in its host-associated habitat. This strain is notable for its single-cell arrangement and optimal growth temperature of 37°C, placing it firmly within the mesophilic temperature range. It possesses two membranes and a single replicon. This bacterium is primarily associated with a range of hosts, including Homo sapiens, Gallus gallus, various Aves, Primates, Mammalia, Amoeba, Rodentia, and Cricetinae. Its pathogenicity in humans is significant, as it is linked to several serious health conditions such as chronic gastric inflammation, peptic ulcer disease, and various forms of gastric cancer, including adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Other health effects attributed to H. pylori infection include gastritis, gastroesophageal reflux disease (GERD), and dyspepsia. The biotic relationship of H. pylori strain ZH68 56 is classified as free living within its host, highlighting its capacity to thrive in the gastric environment of its hosts. The ecological insight gleaned from this strain's pathogenic effects underscores the complex interactions between H. pylori and its host, contributing to a range of gastrointestinal diseases and raising concerns regarding public health, especially in populations with high prevalence rates of infection. This underscores the need for ongoing research into the management and treatment of H. pylori-related health issues.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain ZH68 56

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain ZH68 56
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH68 56, whole genome shotgun sequence.

Gene Summary

Adenine Count

503800 bp

Thymine Count

514143 bp

Guanine Count

329479 bp

Cytosine Count

326302 bp

Genome Length

1677896 bp

Protein-coding Genes

1484 genes

Non-Coding Genes

80 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
cytochrome cEC516_06885Not AvailablePositive1415710 - 141600010293.0
rna pyrophosphohydrolaseEC516_06890Not AvailablePositive1416161 - 141663418737.6
aspartate kinaseEC516_06895Not AvailablePositive1416628 - 141784544184.4
dna replication regulator family proteinEC516_06900Not AvailablePositive1417842 - 141838420979.3
dna polymerase iii subunit delta'EC516_06905Not AvailablePositive1418381 - 141903725368.8
dihydropteroate synthaseEC516_06910Not AvailablePositive1419034 - 142017643192.6
hypothetical proteinEC516_06915Not AvailableNegative1420271 - 142073217306.2
dmt family transporterEC516_06925Not AvailablePositive1421076 - 142198433313.1
hypothetical proteinEC516_06930Not AvailablePositive1421975 - 142322247493.8
duf507 family proteinEC516_06935Not AvailablePositive1423301 - 142385222123.7

Displaying genes 1341 – 1350 of 1564 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total