Escherichia coli strain NGE5

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain NGE5 is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic lifestyle, thriving optimally at 37 degrees Celsius within a mesophilic temperature range. This strain is motile, possessing flagella, and typically exists in pairs or as singles. It is characterized by a biotic relationship that allows it to be free-living while also being host-associated, with a broad range of potential hosts including Homo sapiens, various livestock species (such as Bos taurus and Sus scrofa), birds, and numerous other vertebrates and invertebrates. E. coli NGE5 is notable for its association with various health effects, particularly in humans, where it is implicated in urinary tract infections (UTIs), gastrointestinal infections, and more severe conditions such as neonatal meningitis and hemolytic uremic syndrome (HUS). The strain's pathogenic potential highlights its role in foodborne infections and various complications, including septicemia and colorectal cancer. The strain's adaptability and diverse host range suggest its ecological role is significant, not only as a commensal organism in many species but also as a potential pathogen. Understanding the dynamics of E. coli NGE5 in different environments can provide insights into its transmission and the public health challenges it presents, particularly concerning food safety and zoonotic transmission.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain NGE5

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain NGE5
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain NGE5 NODE_54_length_221_cov_34.0638, whole

Gene Summary

Adenine Count

1146316 bp

Thymine Count

1150010 bp

Guanine Count

1177233 bp

Cytosine Count

1195607 bp

Genome Length

4669166 bp

Protein-coding Genes

4321 genes

Non-Coding Genes

211 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Tail:host specificity proteinDGZ25_00005Not AvailableNegative1 - 112641847.4
Trna-ile;Not AvailableNot AvailablePositive48 - 124Not Available
Trna-asp;Not AvailableNot AvailablePositive50 - 126Not Available
Trna-glu;Not AvailableNot AvailablePositive65 - 140Not Available
Trna-ile;Not AvailableNot AvailablePositive4 - 80Not Available
Trna-ala;Not AvailableNot AvailablePositive167 - 242Not Available
AttlNot AvailableNot AvailablePositive169 - 181Not Available
Trna-asp;Not AvailableNot AvailablePositive170 - 246Not Available
Trna-ile;Not AvailableNot AvailablePositive182 - 258Not Available
Trna-glu;Not AvailableNot AvailablePositive199 - 274Not Available

Displaying genes 1 – 10 of 4532 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total