Escherichia coli strain 12-246M UB12-246M1_c978

Escherichia coli strain 12-246M (UB12-246M1_c978) is a gram-negative bacterium that exhibits a rod shape and is classified as a facultative anaerobe, capable of thriving in both aerobic and anaerobic environments. This strain is motile, possessing flagella that allow for movement. It is adapted to a mesophilic temperature range, with an optimal growth temperature of 37°C. E. coli strain 12-246M is host-associated, exhibiting a free-living biotic relationship while also being adaptable to a wide range of hosts. It has been identified in various organisms including Homo sapiens, Gallus gallus, Bos taurus, and several others across multiple taxa such as mammals and birds. This strain is associated with numerous health effects, particularly in humans, where it can cause urinary tract infections (UTIs), gastrointestinal infections, neonatal meningitis, and even more severe conditions like septicemia and hemolytic uremic syndrome (HUS). The pathogenicity of E. coli strain 12-246M primarily affects humans, leading to a variety of clinical manifestations such as diarrhea, abdominal pain, and, in some cases, severe complications like renal failure and cardiovascular diseases. The diversity of hosts indicates a complex ecological role, potentially contributing to the dynamics of microbial populations in various environments. Furthermore, the strain's association with both human and animal health highlights its significance in understanding zoonotic transmission and the epidemiology of infectious diseases.