Enterococcus faecalis strain 12-8-01

Enterococcus faecalis strain 12-8-01 is a Gram-positive, non-motile coccus and a facultative anaerobe. It thrives as a chemoorganotroph, utilizing organic compounds for energy, and is categorized as mesophilic, with an optimal growth temperature of 37°C. This strain has a single membrane and one replicon, indicating a simple cellular organization. E. faecalis strain 12-8-01 is free-living and can inhabit multiple environments, including human and animal hosts such as Homo sapiens, Gallus gallus, Bos, Metazoa, Lutjanus russellii, Danio rerio, Sus scrofa, Insecta, Canis lupus familiaris, Felis catus, and Phocoena phocoena. This strain is notably pathogenic to humans, associated with a wide range of health effects, including bacteremia, urinary tract infections (UTIs), endocarditis, meningitis, and various nosocomial infections. It can cause infections in diverse body parts, including the urinary tract, intra-abdomen, pelvic regions, surgical sites, and oral cavity. Such a broad spectrum of pathogenicity underscores its clinical significance, particularly in hospital settings where it can lead to serious complications like septicemia and refractory apical periodontitis. The presence of E. faecalis strain 12-8-01 in both the human microbiome and various animal hosts highlights its ecological versatility. Its capacity to thrive in different environments and its potential to cause infections in multiple hosts suggest a complex role in both health and disease, emphasizing the need for careful monitoring and control in clinical settings to mitigate its pathogenic effects.