Aggregatibacter aphrophilus strain HK83

Aggregatibacter aphrophilus strain HK83 is a Gram-negative, facultatively anaerobic rod-shaped bacterium primarily associated with hosts such as Homo sapiens and Canis lupus familiaris. This organism is characterized by having a single replicon and two membranes, which is typical for Gram-negative bacteria. Notably, it is immobile, indicated by the presence of flagella that do not confer motility. This strain thrives in mesophilic temperature ranges, making it well-suited for survival in warm-blooded hosts. Aggregatibacter aphrophilus has been implicated in various serious health conditions, including spondylodiscitis, endocarditis, liver abscesses, brain abscesses, meningitis, and several other infections, such as culture-negative endocarditis and mediastinitis. The organism's pathogenicity in humans highlights its potential as a significant opportunistic pathogen, particularly in immunocompromised individuals. The biotic relationship of Aggregatibacter aphrophilus is categorized as free-living, suggesting a level of independence from its hosts, yet it can also contribute to severe infections. This duality underscores the ecological role of the bacterium in both health and disease. Its presence in diverse infections emphasizes the need for further research into its pathogenic mechanisms and interactions within the host environment. Understanding these dynamics is crucial for developing effective treatments and preventive strategies against the infections caused by this bacterium.