Fusobacterium nucleatum strain 12230

Fusobacterium nucleatum strain 12230 is a Gram-negative, rod-shaped bacterium that thrives in host-associated environments. As a chemoheterotroph, it derives its energy from organic compounds, and it is classified as an anaerobe, indicating that it can grow in the absence of oxygen. This strain is non-motile, despite possessing flagella, and typically exists as pairs in its cellular arrangement. Fusobacterium nucleatum is mesophilic, with an optimal growth temperature of 37°C, which aligns with the average human body temperature, suggesting its adaptation to host environments. This bacterium possesses a unique cellular structure, characterized by two membranes and a single replicon. It has been identified in association with various hosts, including Homo sapiens and Oryctolagus cuniculus, and exhibits a free-living biotic relationship. However, it is also linked to several health issues, notably colorectal cancer, Lemierre's syndrome, gingival diseases, and other dental infections. Its pathogenicity in animals highlights its potential role in disease processes, particularly in chronic oral and intestinal conditions. The presence of Fusobacterium nucleatum in the human microbiome may have significant implications for health, especially regarding its carcinogenic potential and association with systemic diseases. Understanding its ecological role and interactions within the microbiome can provide insights into its contribution to both health and disease states.