Escherichia coli strain NGE-016

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain NGE-016 is a Gram-negative, rod-shaped bacterium that exhibits mobility, characterized by the presence of flagella. This strain is a facultative anaerobe, thriving optimally at 37°C within a mesophilic temperature range. It is biotic, demonstrating a free-living relationship and can be found in various habitats associated with multiple hosts, including mammals such as Homo sapiens, Bos taurus, and Canis lupus familiaris, as well as other organisms like Solanum lycopersicum and Apis mellifera. NGE-016 is notable for its pathogenic potential in humans, being implicated in a wide array of health effects. These include urinary tract infections (UTIs), gastrointestinal infections, peritonitis, and severe conditions such as hemolytic uremic syndrome (HUS) and neonatal meningitis. The strain is also associated with foodborne infections, which can lead to complications like renal failure and diarrhea. Its pathogenicity underscores the importance of this strain in both clinical and public health contexts. Given its diverse host range and the spectrum of diseases it can cause, E. coli strain NGE-016 serves as a critical pathogen in health and disease dynamics. Its presence in various environments and potential for causing infections highlight the ecological significance of this strain in both human and animal health, emphasizing the need for continued surveillance and research to understand its impact on health and disease transmission.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain NGE-016

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain NGE-016
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain NGE-016 NODE_305_length_212_cov_6.67059,

Gene Summary

Adenine Count

1223980 bp

Thymine Count

1220313 bp

Guanine Count

1256252 bp

Cytosine Count

1252374 bp

Genome Length

4952920 bp

Protein-coding Genes

4684 genes

Non-Coding Genes

368 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
succinate dehydrogenase cytochrome b556 subunitDIZ31_11175Not AvailablePositive2195993 - 219638214286.0
succinate dehydrogenase hydrophobic membrane anchor subunitDIZ31_11180Not AvailablePositive2196376 - 219672312868.3
succinate dehydrogenase flavoprotein subunitDIZ31_11185Not AvailablePositive2196723 - 219848964425.6
succinate dehydrogenase iron-sulfur subunitDIZ31_11190Not AvailablePositive2198505 - 219922126785.4
2-oxoglutarate dehydrogenase e1 componentDIZ31_11195Not AvailablePositive2199583 - 2202384105098.0
2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferaseDIZ31_11200Not AvailablePositive2202399 - 220361644042.0
adp-forming succinate--coa ligase subunit betaDIZ31_11205Not AvailablePositive2203710 - 220487641323.1
succinyl-coa ligase subunit alphaDIZ31_11210Not AvailablePositive2204876 - 220574529779.3
gntr family transcriptional regulatorDIZ31_11215Not AvailableNegative2205849 - 220657128232.8
pts 2-o-a-mannosyl-d-glycerate transporter subunit iiabcDIZ31_11220Not AvailablePositive2206740 - 220865667262.0

Displaying genes 2431 – 2440 of 5052 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total