Legionella pneumophila strain HH13

Gram-negativeRodMotileAerobic

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Legionellales

Family

Legionellaceae

Genus

Legionella

Description

Legionella pneumophila strain HH13 is a Gram-negative, mesophilic bacterium that is rod-shaped and exhibits mobility due to the presence of flagella. This organism is classified as a chemoorganotroph, relying on organic compounds for energy. It is aerobic, requiring oxygen for growth, and typically exists in a free-living state. The strain is notably associated with various hosts, including Homo sapiens, several amoebae species such as Acanthamoeba castellanii and Balamuthia mandrillaris, as well as Viridiplantae and Dictyostelium discoideum. This diverse host range suggests that Legionella pneumophila can adapt to various ecological niches, which may facilitate its survival and pathogenic potential. Legionella pneumophila strain HH13 is known for its pathogenicity in humans and animals, being responsible for several health conditions such as pneumonia, specifically Legionnaires' disease and community-acquired pneumonia (CAP). It can also lead to more severe conditions like infectious endocarditis. The strain does not form spores, which may influence its transmission dynamics and environmental persistence. The presence of this bacterium in various environmental and host-associated settings highlights its ecological versatility and pathogenic potential. Its ability to thrive in diverse habitats, combined with its association with amoebae, underscores the importance of understanding its biology for public health, particularly in preventing outbreaks of legionellosis.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderLegionellales
FamilyLegionellaceae
GenusLegionella
SpeciesLegionella pneumophila
Strainstrain HH13

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Legionella pneumophila strain HH13
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Viridiplantae, Acanthamoeba castellanii
Cell arrangementSingles
SporulationNonsporulating
Energy sourceChemoorganotroph
PathogenicityAnimal; Human

Genome Summary

Legionella pneumophila strain HH13

Gene Summary

Adenine Count

1055603 bp

Thymine Count

1038174 bp

Guanine Count

631030 bp

Cytosine Count

665456 bp

Genome Length

3390263 bp

Protein-coding Genes

3007 genes

Non-Coding Genes

50 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinDI056_15170Not AvailableNegative3294339 - 329578755017.4
atpaseDI056_15175Not AvailablePositive3296201 - 329865192957.4
response regulatorDI056_15180Not AvailablePositive3298641 - 329906015848.4
f-box/ankyrin repeat-containing t4ss effector ankbDI056_15185Not AvailableNegative3299091 - 329960919996.2
dehydrogenaseDI056_15190Not AvailablePositive3299842 - 330078335643.3
hypothetical proteinDI056_15195Not AvailableNegative3300878 - 330113810167.3
sdr family nad(p)-dependent oxidoreductaseDI056_15200Not AvailableNegative3301161 - 330199730925.1
transcriptional regulatorDI056_15205Not AvailablePositive3302020 - 330240014702.9
pyridoxamine 5'-phosphate oxidaseDI056_15210Not AvailablePositive3302531 - 330312122816.3
lysr family transcriptional regulatorDI056_15215Not AvailableNegative3303133 - 330404735205.9

Displaying genes 2981 – 2990 of 3057 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

300 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000198tetracenomycin CC23H20O11Chemical structure of tetracenomycin CNot available
Average472.402Da
Monoisotopic472.100561464Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002543-hydroxy-2-methylpropanoateC4H7O3Chemical structure of 3-hydroxy-2-methylpropanoateNot available
Average103.098Da
Monoisotopic103.0400677Da
BASm00002583-(carbamoylamino)propanoateC4H7N2O3Chemical structure of 3-(carbamoylamino)propanoateNot available
Average131.112Da
Monoisotopic131.046215673Da
BASm0000272(E)-4-coumarateC9H7O3Chemical structure of (E)-4-coumarateNot available
Average163.1501Da
Monoisotopic163.0395191Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0000275keto-D-sorboseC6H12O6Chemical structure of keto-D-sorboseNot available
Average180.1559Da
Monoisotopic180.0633881Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da

Displaying 1–10 of 300 metabolites

Health Effects

Health ConditionRelationReference
Community-acquired pneumonia (cap)CausesPMC12584241
PneumoniaCausesPMC12584241
Legionnaires' diseaseCausesPMC2653234
Legionnaires' diseaseCausesPMC3014939
Legionnaires diseaseCausesPMC4379102
Mild diseasesCausesPMC5615607
CapCausesPMC7609860
Legionnaires diseaseCausesPMC8394066
LdCausesPMC8394066
PneumoniaCausesPMC8431511

Displaying health effects 1 – 10 of 45 in total