Prevotella intermedia strain KCOM 2069

Prevotella intermedia strain KCOM 2069 is a Gram-negative, rod-shaped bacterium classified as an anaerobe, meaning it thrives in environments devoid of oxygen. This strain is notably present in diverse habitats, including the gingival sulci, gut, oral cavity, rumen, subgingival and supragingival dental biofilms, subgingival plaque, and the urogenital tract. Its versatility in colonization suggests it possesses adaptations that allow it to persist in various biological niches. The strain has been linked to several health complications in humans, predominantly involving oral health. It is associated with periodontal disease, dental caries, periodontal inflammation, periapical periodontitis, periodontal abscesses, and even more severe conditions such as noma and intracranial infections. These associations highlight its pathogenic potential and the role of Prevotella intermedia in oral microbiome dysbiosis, which can lead to systemic health issues. In addition to its health implications, the presence of Prevotella intermedia in multiple anatomical sites underscores its ecological significance within the human microbiome. The ability to inhabit both the oral cavity and urogenital tract indicates that it may play a complex role in health and disease, potentially influencing microbial community dynamics and host interactions. Understanding the multifaceted roles of this strain could inform strategies for managing oral and systemic health, emphasizing the importance of maintaining a balanced microbiome.