Prevotella intermedia strain KCOM 2833

Prevotella intermedia strain KCOM 2833 is a Gram-negative, anaerobic rod-shaped bacterium primarily associated with the human host, Homo sapiens. This strain thrives in various habitats, including the gingival sulci, oral cavity, gut, rumen, and the urogenital tract. It is also found in dental biofilms, specifically within subgingival and supragingival plaque, where it plays a significant role in oral health and disease. The presence of flagella suggests that Prevotella intermedia has some motility, which may contribute to its ability to colonize diverse environments within the human body. This strain is notable for its pathogenicity, as it has been implicated in multiple health issues, including periodontal disease, dental caries, and various forms of periodontal inflammation. Additionally, it is associated with severe conditions such as periapical periodontitis, periodontal abscesses, noma, and even intracranial infections. The ecological role of Prevotella intermedia in the oral cavity is particularly crucial. By residing in dental biofilms, it can influence the balance of microbial communities, potentially leading to dysbiosis, which is a departure from healthy microbial composition. The pathogenic effects observed in association with this bacterium highlight its importance not only in oral health but also in overall systemic health, emphasizing the need for further understanding of its interactions within the human microbiome.