Bacteroides fragilis strain CM13

Bacteroides fragilis strain CM13 is a Gram-negative, rod-shaped anaerobe that thrives in host-associated environments, primarily within the gastrointestinal tracts of various organisms including Homo sapiens, Gallus gallus, Metazoa, Equidae, and Serpentes. As a chemoorganotroph, it derives energy from organic compounds, which is typical for many gut microbiota. This strain is characterized by its single-cell arrangement and the presence of flagella, though it exhibits no mobility. It has a mesophilic growth range, with an optimal temperature for growth at 37°C, aligning with the body temperature of its primary hosts. Bacteroides fragilis CM13 has a single replicon and is surrounded by a double membrane, which is a common feature of Gram-negative bacteria. In terms of health effects, Bacteroides fragilis strain CM13 has been associated with several serious conditions including bacteremia, abscesses, and various pathologies such as Alzheimer's disease (AD), diarrhea, colitis, and colorectal cancer (CRC). These associations indicate a significant pathogenic potential, particularly in the context of intraabdominal abscesses and localized tissue infections. The ecological role of Bacteroides fragilis CM13 highlights its dual nature as both a free-living organism and a potential pathogen. While it contributes to the microbiota balance in the gut, its pathogenic potential emphasizes the importance of maintaining gut health to prevent adverse health effects, particularly in immunocompromised individuals. Understanding such species is crucial for developing strategies to manage gut microbiota and mitigate disease risks.