Helicobacter pylori strain NCTC12823

Helicobacter pylori strain NCTC12823 is a Gram-negative, microaerophilic bacterium with a spiral shape and a single flagellum, facilitating its motility. This strain is primarily host-associated, thriving in the gastric environment of various hosts, including Homo sapiens, Gallus gallus, and several other mammalian and avian species. Its optimal growth temperature is 37°C, classifying it as mesophilic. Notably, H. pylori NCTC12823 has been implicated in numerous health issues, including chronic gastric inflammation, gastric ulcers, and gastric cancer. The bacterium's pathogenicity in humans is particularly concerning, as it is associated with various gastrointestinal diseases, such as peptic ulcer disease, atrophic gastritis, and mucosa-associated lymphoid tissue (MALT) lymphoma. The strain is known to induce an asymptomatic mucosal inflammatory response, which can progress to more severe conditions, including gastric adenocarcinoma. H. pylori NCTC12823 possesses a single replicon and has a unique biotic relationship characterized as free-living despite its dependence on host environments for survival and reproduction. The presence of two membranes is typical of Gram-negative bacteria and contributes to its resilience in the gastric niche. Understanding the pathogenic mechanisms and ecological interactions of H. pylori NCTC12823 can provide insights into its role in human health and disease, particularly in the context of chronic gastric conditions and the development of gastric cancer. This knowledge is crucial for developing targeted interventions and treatment strategies.