Helicobacter pylori strain NCTC13345

Helicobacter pylori strain NCTC13345 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and single-cell arrangement. It possesses flagella, which aids in its motility, although it is described as non-motile in terms of movement. This strain thrives optimally at 37°C and is classified as mesophilic, allowing it to inhabit warm-blooded hosts. NCTC13345 has a complex biotic relationship, being free-living while also being associated with various hosts, including Homo sapiens, Gallus gallus, and other mammals. This strain is notably pathogenic to humans, contributing to a range of gastrointestinal diseases. It is implicated in chronic gastric inflammation, peptic ulcer disease, and gastric cancers, including adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Other health effects attributed to H. pylori include gastritis, GERD, and dyspepsia, highlighting its significant role in gastrointestinal health. With a single replicon and a double-membrane structure, H. pylori NCTC13345 exemplifies the adaptations seen in pathogenic bacteria that allow them to thrive in hostile environments, such as the human stomach. The presence of this strain in various hosts suggests its ecological versatility and potential for cross-species transmission. Understanding the pathogenic mechanisms and ecological relationships of H. pylori NCTC13345 can provide insights into its role in human health and disease, particularly in the context of chronic gastrointestinal disorders and cancer development.