Haemophilus influenzae strain NCTC11873

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae strain NCTC11873 is a Gram-negative bacterium known for its rod shape and lack of mobility, as it does not possess flagella. This organism is classified as a facultative anaerobe and thrives optimally at a temperature of 35°C, fitting within the mesophilic temperature range. It has a unique cellular structure characterized by two membranes and a single replicon. This strain is primarily associated with Homo sapiens, where it serves as a free-living microorganism. H. influenzae can cause a range of serious health effects, including bacteremia, pneumonia, meningitis, and sepsis. It is also implicated in necrotizing fasciitis, cellulitis, community-acquired pneumonia, and various respiratory infections, including exacerbations of chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Other conditions linked to this bacterium include otitis media, sinusitis, and epiglottitis, illustrating its role in both invasive and noninvasive diseases. The diverse array of infections attributed to H. influenzae strain NCTC11873 underscores its significant impact on human health, particularly in immunocompromised individuals and those with pre-existing respiratory conditions. Understanding the pathogenic potential of this strain is crucial for developing effective treatment strategies and public health measures to mitigate its associated health risks.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
Strainstrain NCTC11873

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae strain NCTC11873
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Haemophilus influenzae strain NCTC11873 chromosome 1, complete

Gene Summary

Adenine Count

605244 bp

Thymine Count

600852 bp

Guanine Count

371999 bp

Cytosine Count

370785 bp

Genome Length

1948880 bp

Protein-coding Genes

1727 genes

Non-Coding Genes

235 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Capsid scaffolding protein oEL230_RS06565Not AvailablePositive1334440 - 133525530569.9
Capsid proteinEL230_RS06570Not AvailablePositive1335277 - 133632638640.1
Terminase endonuclease subunitEL230_RS06575Not AvailablePositive1336338 - 133698824454.4
Head completion/stabilization proteinEL230_RS06580Not AvailablePositive1337281 - 133778718910.1
Tail protein xEL230_RS06585Not AvailablePositive1337787 - 13379967779.3
HolinEL230_RS06590Not AvailablePositive1337998 - 13382198430.98
EndolysinEL230_RS06595Not AvailablePositive1338212 - 133873018924.4
chemotaxis proteinEL230_RS06600Not AvailablePositive1338715 - 133906513600.4
O-spaninEL230_RS09980Not AvailablePositive1338980 - 13392439850.08
Hypothetical proteinEL230_RS06610Not AvailablePositive1339240 - 13394558648.38

Displaying genes 51 – 60 of 1962 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

323 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da
BASm0000642S-adenosyl-4-methylsulfanyl-2-oxobutanoateC15H19N5O6SChemical structure of S-adenosyl-4-methylsulfanyl-2-oxobutanoateNot available
Average397.406Da
Monoisotopic397.105604055Da
BASm0000950L-xyluloseC5H10O5Chemical structure of L-xylulose527-50-4
Average150.1299Da
Monoisotopic150.05282343Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da
BASm0001279(6S)-5-methyl-5,6,7,8-tetrahydrofolateC20H23N7O6Chemical structure of (6S)-5-methyl-5,6,7,8-tetrahydrofolateNot available
Average457.4399Da
Monoisotopic457.1709815Da

Displaying 1–10 of 323 metabolites

Health Effects

Health ConditionRelationReference
Ear infection (otitis media)CausesPMC10964412
Lung infection (pneumonia)CausesPMC10964412
Exacerbations of chronic pulmonary diseases (e.g., chronic obstructive pulmonary disease, protracted bacterial bronchitis, and bronchiectasis)CausesPMC10964412
Ear infectionCausesPMC10964412
Otitis mediaCausesPMC10964412
Lung infectionCausesPMC10964412
PneumoniaCausesPMC10964412
Invasive diseaseCausesPMC10964412
MeningitisCausesPMC11116026
EncephalitisCausesPMC11116026

Displaying health effects 1 – 10 of 60 in total