Klebsiella pneumoniae strain FDAARGOS_775

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain FDAARGOS_775 is a pathogenic, Gram-negative bacterium characterized as a facultative anaerobe and a chemoheterotroph, thriving optimally at 37°C. This mesophilic organism typically exists in various arrangements, including chains, pairs, and singles, and possesses flagella, indicating mobility. The bacterium is nonsporulating and has a complex genomic structure consisting of three replicons. K. pneumoniae is known to have a wide range of hosts, including Homo sapiens, Gallus gallus, and other vertebrates such as Danio rerio and Ovis aries, as well as various invertebrates and plants. This diverse host range highlights its ecological versatility and ability to adapt to different environments. Clinically, K. pneumoniae strain FDAARGOS_775 is associated with numerous health issues, including bacteremia, urinary tract infections, pneumonia, and intra-abdominal infections. The strain can also lead to severe conditions such as sepsis, neonatal sepsis, and various abscesses, demonstrating its significant pathogenic potential in humans. The strain's free-living characteristics suggest that it may thrive in both host-associated and environmental niches, emphasizing its ecological role. Given its pathogenicity, understanding the behavior and transmission of K. pneumoniae strain FDAARGOS_775 is crucial for managing infections and informing public health strategies. This bacterium exemplifies the complex interplay between microbial life and its hosts, underscoring the importance of continued research into its biology and ecology.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain FDAARGOS_775

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain FDAARGOS_775
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain FDAARGOS_775 chromosome, complete

Gene Summary

Adenine Count

1132236 bp

Thymine Count

1127353 bp

Guanine Count

1520260 bp

Cytosine Count

1523186 bp

Genome Length

5303035 bp

Protein-coding Genes

4894 genes

Non-Coding Genes

223 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
diaminobutyrate--2-oxoglutarate transaminaseFIU12_RS19420Not AvailablePositive3948992 - 395037749898.6
pyridoxal phosphate-dependent decarboxylase family proteinFIU12_RS19425Not AvailablePositive3950387 - 395186854042.9
lysr substrate-binding domain-containing proteinFIU12_RS19430Not AvailablePositive3952062 - 395295532182.5
cytochrome c biogenesis protein/redoxinFIU12_RS19435Not AvailableNegative3953752 - 395494242544.2
atp-binding proteinFIU12_RS19440Not AvailableNegative3955045 - 395638849143.6
response regulatorFIU12_RS19445Not AvailableNegative3956385 - 395712528070.1
alpha/beta fold hydrolaseFIU12_RS19450Not AvailableNegative3957212 - 395820436265.9
duf551 domain-containing proteinFIU12_RS19455Not AvailablePositive3958294 - 39584796653.85
pyrroloquinoline quinone precursor peptide pqqaFIU12_RS19460Not AvailablePositive3958513 - 39585842764.48
pyrroloquinoline quinone biosynthesis protein pqqbFIU12_RS19465Not AvailablePositive3958639 - 395956533466.8

Displaying genes 3891 – 3900 of 5268 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total