Escherichia coli strain 2016C-3878

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain 2016C-3878 is a Gram-negative, rod-shaped bacterium that exhibits mobility due to the presence of flagella. It is classified as a facultative anaerobe, allowing it to thrive in various oxygen conditions. This strain is mesophilic, with an optimal growth temperature of 37 degrees Celsius. The habitat of strain 2016C-3878 is primarily host-associated, where it can be found in association with a diverse range of hosts, including Homo sapiens (humans), Gallus gallus (chickens), Bos taurus (cattle), and other animals such as Canis lupus familiaris (domestic dogs) and Felis catus (domestic cats). Additionally, it can associate with various plant species like Solanum lycopersicum (tomato) and Brassica oleracea var. italica (broccoli), reflecting its potential versatility in ecological niches. This strain is implicated in numerous health effects, particularly in humans, where it is associated with urinary tract infections (UTIs), gastrointestinal infections, and severe complications like hemolytic uremic syndrome (HUS) and neonatal meningitis. The extensive list of health impacts suggests that E. coli strain 2016C-3878 plays a significant role in both infectious diseases and foodborne illnesses. The strain possesses two replicons and is characterized by a biotic relationship as a free-living organism, indicating its adaptability in various environments. The presence of this strain across multiple species emphasizes its ecological versatility and potential implications for public health, particularly in relation to zoonotic transmission and food safety.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain 2016C-3878

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain 2016C-3878
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain 2016C-3878 chromosome, complete genome.

Gene Summary

Adenine Count

1237340 bp

Thymine Count

1237176 bp

Guanine Count

1258646 bp

Cytosine Count

1262294 bp

Genome Length

4995456 bp

Protein-coding Genes

4569 genes

Non-Coding Genes

250 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
nadp(h)-dependent aldo-keto reductaseBEN53_RS17580Not AvailablePositive3461784 - 346282438501.7
lysophospholipid transporter lpltBEN53_RS17585Not AvailableNegative3462856 - 346404941626.1
bifunctional acyl-acp--phospholipid o-acyltransferase/long-chain-fatty-acid--acp ligaseBEN53_RS17590Not AvailableNegative3464042 - 346620180744.8
hth-type transcriptional regulator galrBEN53_RS17595Not AvailablePositive3466787 - 346781837121.3
diaminopimelate decarboxylaseBEN53_RS17600Not AvailableNegative3467825 - 346908746159.0
dna-binding transcriptional regulator lysrBEN53_RS17605Not AvailablePositive3469209 - 347014434424.7
amino acid racemaseBEN53_RS17610Not AvailableNegative3470131 - 347082325295.5
arabinose-proton symporter araeBEN53_RS17615Not AvailableNegative3470952 - 347237051687.6
2-dehydro-3-deoxy-d-gluconate 5-dehydrogenase kdudBEN53_RS17620Not AvailableNegative3472685 - 347344627056.7
5-dehydro-4-deoxy-d-glucuronate isomeraseBEN53_RS17625Not AvailableNegative3473476 - 347431231078.1

Displaying genes 3381 – 3390 of 5123 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total