Escherichia coli strain 2016C-3878

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain 2016C-3878 is a Gram-negative, rod-shaped bacterium that exhibits mobility due to the presence of flagella. It is classified as a facultative anaerobe, allowing it to thrive in various oxygen conditions. This strain is mesophilic, with an optimal growth temperature of 37 degrees Celsius. The habitat of strain 2016C-3878 is primarily host-associated, where it can be found in association with a diverse range of hosts, including Homo sapiens (humans), Gallus gallus (chickens), Bos taurus (cattle), and other animals such as Canis lupus familiaris (domestic dogs) and Felis catus (domestic cats). Additionally, it can associate with various plant species like Solanum lycopersicum (tomato) and Brassica oleracea var. italica (broccoli), reflecting its potential versatility in ecological niches. This strain is implicated in numerous health effects, particularly in humans, where it is associated with urinary tract infections (UTIs), gastrointestinal infections, and severe complications like hemolytic uremic syndrome (HUS) and neonatal meningitis. The extensive list of health impacts suggests that E. coli strain 2016C-3878 plays a significant role in both infectious diseases and foodborne illnesses. The strain possesses two replicons and is characterized by a biotic relationship as a free-living organism, indicating its adaptability in various environments. The presence of this strain across multiple species emphasizes its ecological versatility and potential implications for public health, particularly in relation to zoonotic transmission and food safety.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain 2016C-3878

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain 2016C-3878
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain 2016C-3878 chromosome, complete genome.

Gene Summary

Adenine Count

1237340 bp

Thymine Count

1237176 bp

Guanine Count

1258646 bp

Cytosine Count

1262294 bp

Genome Length

4995456 bp

Protein-coding Genes

4569 genes

Non-Coding Genes

250 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
two-component system response regulator glrrBEN53_RS15965Not AvailableNegative3156810 - 315814449152.3
two-component system qseef-associated lipoprotein qsegBEN53_RS15970Not AvailableNegative3158134 - 315884727312.3
two component system sensor histidine kinase qsee/glrkBEN53_RS15975Not AvailableNegative3159012 - 316043953322.6
phosphoribosylformylglycinamidine synthaseBEN53_RS15980Not AvailableNegative3161014 - 3164901141403.0
membrane-bound lytic murein transglycosylase mltfBEN53_RS15985Not AvailablePositive3165158 - 316671458291.2
trna adenosine(34) deaminase tadaBEN53_RS15990Not AvailableNegative3166711 - 316721418736.7
phosphatidylglycerophosphatase cBEN53_RS15995Not AvailableNegative3167272 - 316790724437.8
murr/rpir family transcriptional regulatorBEN53_RS16000Not AvailablePositive3168116 - 316896430679.3
4fe-4s dicluster ferredoxin yfhlBEN53_RS16005Not AvailablePositive3169020 - 31692809805.82
type i toxin-antitoxin system toxin shobBEN53_RS16010Not AvailableNegative3169474 - 31695543103.22

Displaying genes 3121 – 3130 of 5123 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total