Akkermansia muciniphila strain EB-AMDK-18

Gram-negativeCocciNon-motileAnaerobe

Kingdom

Pseudomonadati

Phylum

Verrucomicrobiota

Class

Verrucomicrobiia

Order

Verrucomicrobiales

Family

Akkermansiaceae

Genus

Akkermansia

Description

Akkermansia muciniphila strain EB-AMDK-18 is a Gram-negative, non-motile coccus that thrives in anaerobic environments. This strain is primarily associated with host organisms, specifically Homo sapiens and other Metazoa. Its optimal growth temperature is 37°C, classifying it as mesophilic within a temperature range suited for human body conditions. The organism is characterized by a unique cell arrangement, typically found in singles or pairs, and possesses a double membrane structure. Notably, Akkermansia muciniphila strain EB-AMDK-18 does not form spores, indicating a continuous mode of growth rather than a survival strategy in harsh conditions. This strain is known to have significant implications for human health, being associated with food allergies and the thinning of the jejunum mucus layer. These health effects suggest a complex biotic relationship with the host, wherein the presence or absence of this bacterium could influence gut health and immune responses. The strain's free-living nature indicates it can thrive independently, yet it plays a critical role in the host's microbiome. In conclusion, Akkermansia muciniphila strain EB-AMDK-18 exemplifies the intricate relationship between gut microbiota and host health. Its specific traits underscore its potential as a key player in maintaining gut barrier integrity and influencing host immune functions. Further study of this strain may provide insights into its role in health and disease, particularly concerning digestive health and immune responses.

Taxonomy

KingdomPseudomonadati
PhylumVerrucomicrobiota
ClassVerrucomicrobiia
OrderVerrucomicrobiales
FamilyAkkermansiaceae
GenusAkkermansia
SpeciesAkkermansia muciniphila
Strainstrain EB-AMDK-18

Profile

Physiology
Gram staining propertiesNegative
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Akkermansia muciniphila strain EB-AMDK-18
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Metazoa
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Akkermansia muciniphila strain EB-AMDK-18 chromosome, complete

Gene Summary

Adenine Count

618995 bp

Thymine Count

619226 bp

Guanine Count

768563 bp

Cytosine Count

763340 bp

Genome Length

2770124 bp

Protein-coding Genes

2311 genes

Non-Coding Genes

65 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
4-(cytidine 5'-diphospho)-2-c-methyl-d-erythritol kinaseC1O57_RS02400Not AvailableNegative571701 - 57254930804.3
dna topoisomerase iv subunit bC1O57_RS02405Not AvailablePositive572674 - 57451569548.8
isoprenyl transferaseC1O57_RS02410Not AvailablePositive574487 - 57525129135.3
mannose-1-phosphate guanylyltransferaseC1O57_RS02415Not AvailablePositive575284 - 57634239123.7
holliday junction resolvase ruvxC1O57_RS02420Not AvailablePositive576360 - 57676414376.7
mdr family nadph-dependent oxidoreductaseC1O57_RS02425Not AvailableNegative576956 - 57795736094.8
50s ribosomal protein l28C1O57_RS02430Not AvailablePositive578412 - 5786759848.52
hypothetical proteinC1O57_RS02435Not AvailablePositive578876 - 5791008717.42
glycoside hydrolase family 27 proteinC1O57_RS02440Not AvailableNegative579438 - 58103959131.6
fad:protein fmn transferaseC1O57_RS02445Not AvailableNegative581105 - 58217237308.1

Displaying genes 491 – 500 of 2376 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Food allergyCausesPMC11210198
Thinning of the jejunum mucus layerCausesPMC7527075

Displaying health effects 1 – 2 of 2 in total