Prevotella intermedia strain KCOM 2837

Prevotella intermedia strain KCOM 2837 is a Gram-negative, rod-shaped anaerobic bacterium primarily associated with the human host, specifically Homo sapiens. This microbe is commonly found in various habitats within the human body, including the gingival sulci, oral cavity, gut, urogenital tract, and both subgingival and supragingival dental biofilms. Notably, it resides in subgingival plaque, contributing to its relevance in oral health. This strain possesses true flagella, which may play a role in its motility and colonization within diverse environments. Moreover, it has two replicons, indicating a complex genomic structure that may contribute to its adaptability and pathogenic potential. Prevotella intermedia has been identified as a pathogenic organism associated with several health issues, particularly in the realm of dental and periodontal health. It is implicated in conditions such as periodontal disease, dental caries, periodontal inflammation, periapical periodontitis, and periodontal abscesses. Additionally, it has been linked to more severe health complications, including noma and intracranial infections. The presence of Prevotella intermedia in both healthy and diseased states highlights its dual role within the human microbiome. While it is a natural inhabitant of the oral cavity and gut, its pathogenicity underscores the delicate balance of microbial communities and the potential for dysbiosis, leading to significant health issues. Understanding the ecological niche and pathogenic mechanisms of Prevotella intermedia can inform strategies for managing oral and systemic health.