Capnocytophaga canimorsus strain H5594

Gram-negativeRodNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Bacteroidota

Class

Flavobacteriia

Order

Flavobacteriales

Family

Flavobacteriaceae

Genus

Capnocytophaga

Description

Capnocytophaga canimorsus strain H5594 is a Gram-negative, microaerophilic, rod-shaped bacterium. It is classified as a chemoheterotroph, utilizing organic compounds for energy. This strain is non-motile and possesses flagella, although its primary habitat encompasses multiple environments. The optimal growth temperature for strain H5594 is 37°C, indicating its mesophilic nature. This bacterium has been identified in association with various hosts, including humans (Homo sapiens), domestic cats (Felis catus), and dogs (Canis lupus familiaris). Its free-living biotic relationship suggests that it can survive independently in diverse ecological niches. Notably, Capnocytophaga canimorsus strain H5594 is linked to several serious health effects, including bacteremia, endocarditis, meningitis, and various systemic infections like sepsis and septicemia. It is particularly concerning in cases of local wound infections and severe generalized infections, which may arise from interactions with its animal hosts. The presence of Capnocytophaga canimorsus in humans primarily occurs following close contact with pets, especially dogs and cats, highlighting the zoonotic potential of this organism. Understanding its pathogenic profile is crucial for managing infections and preventing severe health outcomes associated with this bacterium. The strain's non-sporulating nature further emphasizes the importance of direct contact in its transmission dynamics, offering insight into its ecological role and implications for public health.

Taxonomy

KingdomPseudomonadati
PhylumBacteroidota
ClassFlavobacteriia
OrderFlavobacteriales
FamilyFlavobacteriaceae
GenusCapnocytophaga
SpeciesCapnocytophaga canimorsus
Strainstrain H5594

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranesNot Available
Image of Capnocytophaga canimorsus strain H5594
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Homo sapiens, Metazoa, Canis lupus familiaris
Cell arrangementNot Available
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityNot Available

Genome Summary

Capnocytophaga canimorsus strain H5594


Gene Summary

Adenine Count

797950 bp

Thymine Count

793845 bp

Guanine Count

452328 bp

Cytosine Count

449705 bp

Genome Length

2493828 bp

Protein-coding Genes

2226 genes

Non-Coding Genes

56 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
low molecular weight protein-tyrosine-phosphataseCGC56_RS00010Not AvailablePositive1291 - 175217145.3
sam-dependent methyltransferaseCGC56_RS00015Not AvailablePositive1768 - 246925752.4
sodium:solute symporterCGC56_RS00020Not AvailableNegative2459 - 387752883.2
anhydro-n-acetylmuramic acid kinaseCGC56_RS00025Not AvailableNegative3984 - 506340446.2
orotidine-5'-phosphate decarboxylaseCGC56_RS00030Not AvailablePositive5466 - 627830262.1
type i phosphomannose isomerase catalytic subunitCGC56_RS00035Not AvailableNegative6279 - 724136698.6
ig-like domain-containing proteinCGC56_RS00040Not AvailablePositive7478 - 889351048.9
tlpa family protein disulfide reductaseCGC56_RS00045Not AvailableNegative9166 - 1053352461.9
protein translocase subunit secdfCGC56_RS00050Not AvailablePositive10808 - 13753107622.0
dihydrolipoyl dehydrogenaseCGC56_RS00055Not AvailablePositive13903 - 1530950746.5

Displaying genes 1 – 10 of 2282 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

25 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00005275-oxopentanoateC5H7O3Chemical structure of 5-oxopentanoateNot available
Average115.109Da
Monoisotopic115.040067665Da
BASm0001111keto-D-tagaturonateC6H9O7Chemical structure of keto-D-tagaturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001514Fe(III)-enterobactinC30H21FeN3O15Chemical structure of Fe(III)-enterobactinNot available
Average719.344Da
Monoisotopic719.0322092Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002051D-fructoseC6H12O6Chemical structure of D-fructose57-48-7
Average180.1559Da
Monoisotopic180.0633881Da
BASm00021577-cyano-7-deazaguanineC7H5N5OChemical structure of 7-cyano-7-deazaguanineNot available
Average175.1475Da
Monoisotopic175.0494098Da
BASm0002981N(6)-hydroxy-L-lysineC6H14N2O3Chemical structure of N(6)-hydroxy-L-lysineNot available
Average162.189Da
Monoisotopic162.1004423Da

Displaying 1–10 of 25 metabolites

Health Effects

Health ConditionRelationReference
Local wound infectionsCausesPMC10269634
Lethal sepsisCausesPMC10269634
Systemic infectionsCausesPMC10269634
CellulitisCausesPMC10269634
MeningitisCausesPMC10269634
SepsisCausesPMC10269634
BacteremiaCausesPMC10972404
MeningitisCausesPMC10972404
Infective endocarditisCausesPMC10972404
IeCausesPMC10972404

Displaying health effects 1 – 10 of 28 in total