Escherichia coli O157:H7 strain PA20

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli O157:H7 strain PA20 is a Gram-negative, rod-shaped bacterium characterized by its mobility and the presence of flagella. As a facultative anaerobe, it can thrive in both aerobic and anaerobic environments, making it adaptable to a variety of habitats. This strain is host-associated, primarily found in organisms such as Homo sapiens (humans), Bos taurus (cattle), Bos (bovines), Sus scrofa (swine), and Oryctolagus cuniculus (rabbits). E. coli O157:H7 strain PA20 has a mesophilic temperature range, with an optimal growth temperature of 37°C. It possesses a single replicon and is structured with two membranes, typical of Gram-negative bacteria. The bacterium exhibits a free-living biotic relationship, indicating its capacity to exist independently in various environments, although it often resides in the gastrointestinal tracts of its hosts. This strain of E. coli is notable for its health effects in humans, which can include diarrhea, hemorrhagic diarrhea, renal failure, anemia, and hemolytic uremic syndrome (HUS). These severe health implications underscore the strain's pathogenic potential, particularly in foodborne outbreaks. Understanding the ecological role of E. coli O157:H7 strain PA20 in various hosts can provide insights into its transmission dynamics and the public health risks associated with its presence in the food supply chain.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
StrainO157:H7 strain PA20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli O157:H7 strain PA20
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Bos taurus, Bos
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Escherichia coli O157:H7 strain PA20 plasmid pO157, complete

Gene Summary

Adenine Count

24872 bp

Thymine Count

23752 bp

Guanine Count

23870 bp

Cytosine Count

20261 bp

Genome Length

92755 bp

Protein-coding Genes

95 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinAU473_RS28755Not AvailableNegative69655 - 698406876.23
catalase/peroxidase katpAU473_RS28760Not AvailablePositive70017 - 7222781798.5
cytochrome b562AU473_RS28765Not AvailablePositive72271 - 7266014582.7
transposaseAU473_RS28775Not AvailablePositive72717 - 7370537670.6
serine protease autotransporter esppAU473_RS28780Not AvailablePositive73886 - 77788141766.0
transposaseAU473_RS31320Not AvailableNegative78044 - 7852518181.3
polysaccharide deacetylase family proteinAU473_RS28795Not AvailablePositive79967 - 8078832191.6
glycosyltransferase family 4 proteinAU473_RS28800Not AvailablePositive80788 - 8189440857.1
phosphoethanolamine transferase cptaAU473_RS28805Not AvailablePositive81984 - 8370566240.1
lauroyl-kdo(2)-lipid iv(a) myristoyltransferaseAU473_RS28810Not AvailablePositive83779 - 8477737860.3

Displaying genes 81 – 90 of 95 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
DiarrheaCausesPMC3035056
Hemorrhagic diarrheaCausesPMC4726323
Renal failureCausesPMC4726323
AnemiaCausesPMC4726323
HusCausesPMC7320338
Hemolytic uremic syndromeCausesPMC7320338
Hemorrhagic colitisCausesPMC13022023
HusCausesPMC13022023
Hemolytic uremic syndromeCausesPMC3338595
Hemorrhagic colitisCausesPMC3667801

Displaying health effects 1 – 10 of 12 in total