Klebsiella pneumoniae strain PMK1

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain PMK1 is a Gram-negative, rod-shaped bacterium that is primarily host-associated. As a chemoheterotroph, it obtains energy through the consumption of organic compounds. This strain exhibits a facultative anaerobic metabolism, allowing it to thrive in both aerobic and anaerobic environments, with an optimal growth temperature of 37°C, placing it in the mesophilic temperature range. Morphologically, K. pneumoniae PMK1 can be found in various arrangements, including singles, pairs, and chains. It possesses flagella, which contribute to its mobility. The bacterium is nonsporulating and contains five replicons and two membranes, characteristic of members of the Enterobacteriaceae family. Klebsiella pneumoniae PMK1 has a wide host range, infecting various organisms, including humans (Homo sapiens), avians (Gallus gallus, Phasianidae), and several mammals (Canis lupus familiaris, Sus scrofa, Equidae, etc.). It is associated with numerous health complications, particularly in humans, where it can lead to serious conditions such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The ecological insight from K. pneumoniae PMK1 is its adaptability to multiple host species and environments, reflecting its capacity to be a significant opportunistic pathogen. Its presence in diverse hosts suggests that it plays a role in complex microbial ecosystems, where it can influence health outcomes and contribute to the dynamics of infectious disease transmission.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain PMK1

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain PMK1
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain PMK1


Gene Summary

Adenine Count

1134243 bp

Thymine Count

1129303 bp

Guanine Count

1527491 bp

Cytosine Count

1525964 bp

Genome Length

5317001 bp

Protein-coding Genes

4950 genes

Non-Coding Genes

170 genes

# of Chromosomes/Plasmids

5

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Diguanylate cyclase domain proteinPMK1_RS18445Not AvailableNegative3799503 - 380051637649.8
AttlNot AvailableNot AvailablePositive3800648 - 3800669Not Available
IntegrasePMK1_RS18450Not AvailableNegative3800781 - 380176437205.8
Xre family transcriptional regulatorPMK1_RS18455Not AvailableNegative3801880 - 380217911174.4
Regulatory proteinPMK1_RS18460Not AvailablePositive3802300 - 380257810301.5
Hypothetical proteinPMK1_RS18465Not AvailablePositive3802599 - 38028178421.27
Hypothetical proteinPMK1_RS18470Not AvailablePositive3802833 - 380321014680.7
Hypothetical proteinPMK1_RS18475Not AvailablePositive3803226 - 380348910453.6
Hypothetical proteinPMK1_RS18480Not AvailablePositive3803567 - 38037918208.83
3'-5' exoribonucleasePMK1_RS18485Not AvailablePositive3803800 - 380435420573.6

Displaying genes 1 – 10 of 5832 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 49 in total