Klebsiella pneumoniae strain KpvST48_NDM

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain KpvST48_NDM is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, classifying it as a chemoheterotroph. This strain is known for its mobility, attributed to the presence of flagella, and it typically forms chains, pairs, or singles in its cell arrangement. It thrives optimally at 37°C, placing it in the mesophilic temperature range. KpvST48_NDM is associated with various hosts, including Homo sapiens, Gallus gallus, and other metazoans and plants. This wide host range indicates its adaptability and potential for transmission across different species. The strain is pathogenic to humans, causing a range of serious health issues, such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The variety of infections it can cause highlights its clinical significance and the need for ongoing surveillance and management strategies. The strain possesses five replicons and two membranes, characteristic of its complex genetic architecture. Notably, KpvST48_NDM is nonsporulating, which influences its survival strategies and ecological interactions. In summary, the broad host range and significant pathogenicity of Klebsiella pneumoniae strain KpvST48_NDM underscore its role as an opportunistic pathogen in both human health and environmental contexts. Its ability to thrive in diverse habitats and cause severe infections demonstrates the importance of understanding its biology and the implications for public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain KpvST48_NDM

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain KpvST48_NDM
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain KpvST48_NDM plasmid unnamed1, whole

Gene Summary

Adenine Count

673 bp

Thymine Count

707 bp

Guanine Count

607 bp

Cytosine Count

659 bp

Genome Length

2646 bp

Protein-coding Genes

3 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

5

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinFFY37_16705Not AvailablePositive3445596 - 344587710824.1
fumarylacetoacetate hydrolase family proteinFFY37_16710Not AvailablePositive3445894 - 344655323733.7
ycgn family cysteine cluster proteinFFY37_16715Not AvailablePositive3446648 - 344709417215.4
duf1971 domain-containing proteinFFY37_16720Not AvailableNegative3447101 - 344744512765.0
disulfide bond formation protein dsbbFFY37_16725Not AvailableNegative3447596 - 344812620066.3
sodium/proton antiporter nhabFFY37_16730Not AvailableNegative3448255 - 344980556728.0
fatty acid metabolism transcriptional regulator fadrFFY37_16735Not AvailablePositive3450054 - 345077327090.4
spovr family proteinFFY37_16740Not AvailableNegative3450848 - 345238060578.7
d-amino acid dehydrogenase small subunitFFY37_16745Not AvailablePositive3452702 - 345400047203.8
catabolic alanine racemase dadxFFY37_16750Not AvailablePositive3454010 - 345508038734.0

Displaying genes 3281 – 3290 of 5110 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total