Klebsiella pneumoniae strain KpvST48_NDM

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Klebsiella

Description

Klebsiella pneumoniae strain KpvST48_NDM is a Gram-negative, rod-shaped bacterium that exhibits a facultative anaerobic metabolism, classifying it as a chemoheterotroph. This strain is known for its mobility, attributed to the presence of flagella, and it typically forms chains, pairs, or singles in its cell arrangement. It thrives optimally at 37°C, placing it in the mesophilic temperature range. KpvST48_NDM is associated with various hosts, including Homo sapiens, Gallus gallus, and other metazoans and plants. This wide host range indicates its adaptability and potential for transmission across different species. The strain is pathogenic to humans, causing a range of serious health issues, such as bacteremia, urinary tract infections, pneumonia, and sepsis, among others. The variety of infections it can cause highlights its clinical significance and the need for ongoing surveillance and management strategies. The strain possesses five replicons and two membranes, characteristic of its complex genetic architecture. Notably, KpvST48_NDM is nonsporulating, which influences its survival strategies and ecological interactions. In summary, the broad host range and significant pathogenicity of Klebsiella pneumoniae strain KpvST48_NDM underscore its role as an opportunistic pathogen in both human health and environmental contexts. Its ability to thrive in diverse habitats and cause severe infections demonstrates the importance of understanding its biology and the implications for public health.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusKlebsiella
SpeciesKlebsiella pneumoniae
Strainstrain KpvST48_NDM

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Klebsiella pneumoniae strain KpvST48_NDM
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Metazoa
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityHuman

Genome Summary

Klebsiella pneumoniae strain KpvST48_NDM plasmid unnamed1, whole

Gene Summary

Adenine Count

673 bp

Thymine Count

707 bp

Guanine Count

607 bp

Cytosine Count

659 bp

Genome Length

2646 bp

Protein-coding Genes

3 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

5

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
microcin c abc transporter permease yejbFFY37_14870Not AvailableNegative3055874 - 305696840211.6
abc transporter substrate-binding proteinFFY37_14875Not AvailableNegative3056978 - 305878369092.0
cyclic di-gmp phosphodiesteraseFFY37_14880Not AvailableNegative3058852 - 306041457592.1
bifunctional murein dd-endopeptidase/murein ld-carboxypeptidaseFFY37_14885Not AvailableNegative3060602 - 306117120998.9
phosphatase pap2 family proteinFFY37_14890Not AvailableNegative3061598 - 306230526122.7
gtp-binding proteinFFY37_14895Not AvailableNegative3062349 - 306332635718.9
mannonate dehydrataseFFY37_14905Not AvailablePositive3065120 - 306631044772.3
elongation factor p-like protein yeipFFY37_14910Not AvailableNegative3066381 - 306695321513.9
ykgj family cysteine cluster proteinFFY37_14915Not AvailablePositive3067101 - 30673559084.17
sugar efflux transporter setbFFY37_14920Not AvailableNegative3067395 - 306857642863.7

Displaying genes 2931 – 2940 of 5110 in total

Metabolites

1246 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 1246 metabolites

Health Effects

Health ConditionRelationReference
Mink pneumoniaCausesPMC11316373
EnteritisCausesPMC11316373
Urinary tract infectionCausesPMC11316373
CystitisCausesPMC11316373
PneumoniaCausesPMC11316373
MeningitisCausesPMC11316373
Liver abscessCausesPMC11316373
Endogenous endophthalmitisCausesPMC11316373
SepsisCausesPMC11316373
PneumoniaCausesPMC12198309

Displaying health effects 1 – 10 of 53 in total