Cutibacterium acnes strain P15-206

Cutibacterium acnes strain P15-206 is a Gram-positive, non-motile rod that thrives in anaerobic conditions. This strain is associated with human hosts, specifically Homo sapiens, and is categorized as mesophilic, with an optimal growth temperature of 37°C. It possesses a single membrane and one replicon, indicating a simplified cellular structure typical of many anaerobic bacteria. C. acnes is known to have a complex role in human health. While it is often recognized for its association with common acne, it is also implicated in more severe health conditions such as acute bacterial meningitis, thoracic actinomycosis, and infectious complications following vertebroplasty or kyphoplasty. Additionally, there is evidence suggesting a potential link between this bacterium and epithelial ovarian cancer. The ecological role of C. acnes extends beyond pathogenicity; it is a free-living organism that can be part of the normal human skin microbiome. This duality highlights the importance of C. acnes in both health and disease contexts. Its presence in skin microbiota contributes to the maintenance of skin homeostasis, although dysbiosis can lead to various health issues. Understanding the balance of C. acnes in the human microbiome is crucial for developing strategies to manage its pathogenic effects while preserving its beneficial roles. The strain's accession number is NXAR00000000.1, which can be used for further genomic studies.