Mycobacterium tuberculosis str. Erdman = ATCC 35801

Gram-positiveRodNon-motileAerobic

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Mycobacteriaceae

Genus

Mycobacterium

Description

Mycobacterium tuberculosis str. Erdman, also known as ATCC 35801, is a significant pathogen responsible for tuberculosis in humans. This bacterium is classified as a Gram-positive, aerobic, rod-shaped organism that typically presents as single cells. It is a chemoorganotroph, meaning it derives its energy from organic compounds, and it thrives optimally at a temperature of 37°C, which is aligned with human body temperature. M. tuberculosis str. Erdman possesses a single membrane and one replicon, indicating a streamlined genetic structure. Notably, it is non-motile and does not have flagella, which suggests that its pathogenicity relies on its ability to persist within host environments rather than mobility. The strain is categorized as free-living, indicating that while it is host-associated, it has adaptations that allow it to exist outside of host organisms under certain conditions. The ecological significance of M. tuberculosis str. Erdman lies in its capacity to infect human hosts and establish a persistent infection, contributing to the public health burden of tuberculosis. As an aerobic organism, it requires oxygen for survival, which is consistent with its growth in the lungs of infected individuals. Understanding the traits of this strain can inform treatment strategies and public health initiatives aimed at controlling and preventing tuberculosis transmission in human populations.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderMycobacteriales
FamilyMycobacteriaceae
GenusMycobacterium
SpeciesMycobacterium tuberculosis
StrainErdman = ATCC 35801

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Mycobacterium tuberculosis str. Erdman = ATCC 35801
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementSingles
SporulationNot Available
Energy sourceChemoorganotroph
PathogenicityNot Available

Genome Summary

Mycobacterium tuberculosis str. Erdman = ATCC 35801 chromosome 1,

Gene Summary

Adenine Count

755858 bp

Thymine Count

756731 bp

Guanine Count

1436491 bp

Cytosine Count

1443273 bp

Genome Length

4392353 bp

Protein-coding Genes

4083 genes

Non-Coding Genes

72 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
ms4527a family cys-rich leader peptideERDMAN_RS23665Not AvailablePositive2673459 - 26735152101.68
sulfite reductase siraERDMAN_RS12570Not AvailablePositive2673630 - 267529762115.0
phosphoadenylyl-sulfate reductaseERDMAN_RS12575Not AvailablePositive2675294 - 267605827424.4
sirohydrochlorin chelataseERDMAN_RS12580Not AvailablePositive2676055 - 267690029783.2
gamma-glutamyltransferaseERDMAN_RS12585Not AvailablePositive2676937 - 267886866577.3
opt family oligopeptide transporterERDMAN_RS12590Not AvailablePositive2678999 - 268100268255.9
acid and phagosome regulated protein apraERDMAN_RS12595Not AvailablePositive2681151 - 26813667927.51
acid and phagosome regulated protein aprbERDMAN_RS12600Not AvailablePositive2681478 - 26816425755.03
pe family proteinERDMAN_RS12605Not AvailablePositive2681726 - 268281130767.4
sulfate/molybdate abc transporter atp-binding proteinERDMAN_RS12610Not AvailableNegative2682836 - 268389137446.0

Displaying genes 2561 – 2570 of 4155 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

7 records
Metabolite IDMetabolite nameStructureCAS number
BASm0002002glyoxylateC2HO3Chemical structure of glyoxylateNot available
Average73.0275Da
Monoisotopic72.9925689Da
BASm00030222-methyl-cis-aconitateC7H5O6Chemical structure of 2-methyl-cis-aconitateNot available
Average185.113Da
Monoisotopic185.0102586Da
BASm0017292Phosphoadenosine phosphosulfateC10H15N5O13P2SChemical structure of Phosphoadenosine phosphosulfate482-67-7
Average507.264Da
Monoisotopic506.986229305Da
BASm0019007(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylateC7H10O7Chemical structure of (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylateNULL
Average206.1501Da
Monoisotopic206.042652674Da
BASm0039653Enterococcus gallinarumNot available20074-52-6Not available
BASm0039655Achromobacter xylosoxidans A8Not availableNot availableNot available
BASm0040411Propionibacterium freudenreichii subsp. shermaniiNot availableNot availableNot available

Displaying 1–7 of 7 metabolites

Health Effects

No health effects information available for this bacterium.